Seroatlas · Human Serome Atlas

REEP3

Receptor expression-enhancing protein 3

Also known as: C10orf74, REEP3_HUMAN, Yip2b

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NUK4
Gene: REEP3
Ensembl: ENSG00000165476
Chromosome: 10
Canonical length: 255 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Involved in mitotic nuclear membrane reassembly. Predicted to be located in endoplasmic reticulum; membrane; and microtubule. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>Q6NUK4|REEP3
     1  MVSWMISRAV VLVFGMLYPA YYSYKAVKTK NVKEYVRWMM YWIVFALYTV IETVADQTVA
    61  WFPLYYELKI AFVIWLLSPY TKGASLIYRK FLHPLLSSKE REIDDYIVQA KERGYETMVN
   121  FGRQGLNLAA TAAVTAAVKS QGAITERLRS FSMHDLTTIQ GDEPVGQRPY QPLPEAKKKS
   181  KPAPSESAGY GIPLKDGDEK TDEEAEGPYS DNEMLTHKGL RRSQSMKSVK TTKGRKEVRY
   241  GSLKYKVKKR PQVYF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REEP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 28 nTPM
parathyroid gland: 27 nTPM
small intestine: 27 nTPM
duodenum: 27 nTPM
adipose tissue: 25 nTPM
smooth muscle: 24 nTPM

Single-cell type

late primary spermatocytes: 471 nCPM
early spermatids: 345 nCPM
prostatic club cells: 340 nCPM
esophageal apical cells: 338 nCPM
urothelial cells: 327 nCPM
pituicytes/fscs: 293 nCPM

Immune cell

T-reg: 5.1 nTPM
intermediate monocyte: 4.6 nTPM
memory CD4 T-cell: 3.4 nTPM
classical monocyte: 3.3 nTPM
MAIT T-cell: 3.3 nTPM
plasmacytoid DC: 3.1 nTPM

Brain region

white matter: 75 nTPM
medulla oblongata: 54 nTPM
basal ganglia: 48 nTPM
midbrain: 46 nTPM
cerebellum: 46 nTPM
choroid plexus: 45 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about REEP3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 43 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual developmental disorder, autosomal dominant 70

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0.02
gnomAD missense Z: 1.08
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of REEP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REEP3 as an antibody target. Whether an autoantibody or antibody against REEP3 could matter depends on whether native REEP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REEP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label REEP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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