Seroatlas · Human Serome Atlas

RANBP6

Ran-binding protein 6

Also known as: RNBP6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60518
Gene: RANBP6
Ensembl: ENSG00000137040
Chromosome: 9
Canonical length: 1105 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1105 residues, UniProt reviewed canonical sequence.

>O60518|RANBP6
     1  MAATASAGVP ATVSEKQEFY QLLKNLINPS CMVRRQAEEI YENIPGLCKT TFLLDAVRNR
    61  RAGYEVRQMA AALLRRLLSS GFEEVYPNLP ADVQRDVKIE LILAVKLETH ASMRKKLCDI
   121  FAVLARNLID EDGTNHWPEG LKFLIDSIYS KNVVLWEVAL HVFWHFPGIF GTQERHDLDI
   181  IKRLLDQCIQ DQEHPAIRTL SARAAAAFVL ANENNIALFK DFADLLPGIL QAVNDSCYQD
   241  DDSVLESLVE IADTVPKYLG PYLEDTLQLS LKLCGDSRLS NLQRQLALEV IVTLSETATP
   301  MLKKHTNIIA QAVPHILAMM VDLQDDEDWV NADEMEEDDF DSNAVAAESA LDRLACGLGG
   361  KVVLPMTKEH IMQMLQSPDW KYRHAGLMAL SAIGEGCHQQ MESILDETVN SVLLFLQDPH
   421  PRVRAAACTT LGQMATDFAP NFQKKFHETV IAALLRTMEN QGNQRVQSHA ASALIIFIED
   481  CPKSLLVLYV DSMVKNLHSV LVIKLQELIR NGTKLALEQL VTTIASVADT IEEKFVPYYD
   541  IFMPSLKHIV ELAVQKELKL LRGKTIECIS HIGLAVGKEK FMQDASNVMQ LLLKTQSDLN
   601  NMEDDDPQTS YMVSAWARMC KILGKDFQQY LPLVIEPLIK TASAKPDVAL LDTQDVENMS
   661  DDDGWQFVNL GDQQSFGIKT SGLEAKATAC QMLVYYAKEL REGFVEYTEQ VVKLMVPLLK
   721  FYFHDNVRVA AAESMPFLLE CARIRGPEYL AQMWQFICDP LIKAIGTEPD TDVLSEIMNS
   781  FAKSIEVMGD GCLNDEHLEE LGGILKAKLE GHFKNQELRQ VKRQEENYDQ QVEMSLQDED
   841  ECDVYILTKV SDILHSLFST YKEKILPWFE QLLPLIVNLI CSSRPWPDRQ WGLCIFDDII
   901  EHCSPTSFKY VEYFRWPMLL NMRDNNPEVR QAAAYGLGVM AQFGGDDYRS LCSEAVPLLV
   961  KVIKCANSKT KKNVIATENC ISAIGKILKF KPNCVNVDEV LPHWLSWLPL HEDKEEAIQT
  1021  LSFLCDLIES NHPVVIGPNN SNLPKIISII AEGKINETIN YEDPCAKRLA NVVRQVQTSE
  1081  DLWLECVSQL DDEQQEALQE LLNFA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RANBP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 29 nTPM
retina: 20 nTPM
thymus: 18 nTPM
lymph node: 16 nTPM
skeletal muscle: 15 nTPM
tonsil: 15 nTPM

Single-cell type

alveolar cells type 1: 38 nCPM
corticotrophs: 30 nCPM
choroid plexus epithelial cells: 28 nCPM
megakaryocytes: 25 nCPM
pancreatic islet cells: 24 nCPM
neutrophil progenitors: 24 nCPM

Immune cell

intermediate monocyte: 6.3 nTPM
non-classical monocyte: 5.3 nTPM
T-reg: 5.2 nTPM
basophil: 5.1 nTPM
classical monocyte: 4.5 nTPM
naive CD4 T-cell: 4.4 nTPM

Brain region

choroid plexus: 40 nTPM
pons: 25 nTPM
cerebellum: 25 nTPM
medulla oblongata: 24 nTPM
cerebral cortex: 23 nTPM
hypothalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0
gnomAD missense Z: -0.33
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein import into nucleus

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RANBP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RANBP6 as an antibody target. Whether an autoantibody or antibody against RANBP6 could matter depends on whether native RANBP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RANBP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RANBP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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