Seroatlas · Human Serome Atlas

ARMCX3

Armadillo repeat-containing X-linked protein 3

Also known as: ALEX3, ARMX3_HUMAN, GASP6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UH62
Gene
ARMCX3
Ensembl
ENSG00000102401
Chromosome
X
Canonical length
379 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

379 residues, UniProt reviewed canonical sequence.

>Q9UH62|ARMCX3
     1  MGYARKVGWV TAGLVIGAGA CYCIYRLTRG RKQNKEKMAE GGSGDVDDAG DCSGARYNDW
    61  SDDDDDSNES KSIVWYPPWA RIGTEAGTRA RARARARATR ARRAVQKRAS PNSDDTVLSP
   121  QELQKVLCLV EMSEKPYILE AALIALGNNA AYAFNRDIIR DLGGLPIVAK ILNTRDPIVK
   181  EKALIVLNNL SVNAENQRRL KVYMNQVCDD TITSRLNSSV QLAGLRLLTN MTVTNEYQHM
   241  LANSISDFFR LFSAGNEETK LQVLKLLLNL AENPAMTREL LRAQVPSSLG SLFNKKENKE
   301  VILKLLVIFE NINDNFKWEE NEPTQNQFGE GSLFFFLKEF QVCADKVLGI ESHHDFLVKV
   361  KVGKFMAKLA EHMFPKSQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMCX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
99 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 99 nTPM
  • parathyroid gland: 97 nTPM
  • tongue: 59 nTPM
  • salivary gland: 56 nTPM
  • adrenal gland: 56 nTPM
  • pancreas: 51 nTPM

Single-cell type

  • epididymal principal cells: 328 nCPM
  • platelets: 283 nCPM
  • syncytiotrophoblasts: 151 nCPM
  • epididymal clear cells: 137 nCPM
  • mast cells: 136 nCPM
  • plasma cells: 136 nCPM

Immune cell

  • basophil: 44 nTPM
  • plasmacytoid DC: 26 nTPM
  • MAIT T-cell: 18 nTPM
  • non-classical monocyte: 17 nTPM
  • intermediate monocyte: 16 nTPM
  • myeloid DC: 16 nTPM

Brain region

  • hypothalamus: 68 nTPM
  • white matter: 64 nTPM
  • spinal cord: 62 nTPM
  • cerebral cortex: 62 nTPM
  • cerebellum: 61 nTPM
  • thalamus: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0.46
gnomAD missense Z
1.74
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARMCX3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMCX3 as an antibody target. Whether an autoantibody or antibody against ARMCX3 could matter depends on whether native ARMCX3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMCX3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMCX3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARMCX3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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