Seroatlas · Human Serome Atlas

FAM114A1

Protein NOXP20

Also known as: Noxp20, NXP20_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWE2
Gene: FAM114A1
Ensembl: ENSG00000197712
Chromosome: 4
Canonical length: 563 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the FAM114 family and may play a role in neuronal cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

563 residues, UniProt reviewed canonical sequence.

>Q8IWE2|FAM114A1
     1  MSDDAGDTLA TGDKAEVTEM PNSDSLPEDA EVHCDSAAVS HEPTPADPRG EGHENAAVQG
    61  AGAAAIGPPV QPQDANALEP PLNGDVTEDT LAECIDSVSL EAEPRSEIPL QEQNYLAVDS
   121  PPSGGGWAGW GSWGKSLLSS ASATVGHGLT AVKEKAGATL RIHGVNSGSS EGAQPNTENG
   181  VPEITDAATD QGPAESPPTS PSSASRGMLS AITNVVQNTG KSVLTGGLDA LEFIGKKTMN
   241  VLAESDPGFK RTKTLMERTV SLSQMLREAK EKEKQRLAQQ LTMERTAHYG MLFDEYQGLS
   301  HLEALEILSN ESESKVQSFL ASLDGEKLEL LKNDLISIKD IFAAKELENE ENQEEQGLEE
   361  KGEEFARMLT ELLFELHVAA TPDKLNKAMK RAHDWVEEDQ TVVSVDVAKV SEEETKKEEK
   421  EEKSQDPQED KKEEKKTKTI EEVYMSSIES LAEVTARCIE QLHKVAELIL HGQEEEKPAQ
   481  DQAKVLIKLT TAMCNEVASL SKKFTNSLTT VGSNKKAEVL NPMISSVLLE GCNSTTYIQD
   541  AFQLLLPVLQ VSHIQTSCLK AQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM114A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

smooth muscle: 58 nTPM
salivary gland: 58 nTPM
liver: 51 nTPM
cervix: 45 nTPM
adrenal gland: 45 nTPM
ovary: 39 nTPM

Single-cell type

lacrimal acinar cells: 345 nCPM
salivary ionocytes: 271 nCPM
esophageal apical cells: 265 nCPM
salivary acinar cells: 222 nCPM
leydig cells: 174 nCPM
goblet cells: 167 nCPM

Immune cell

intermediate monocyte: 3.6 nTPM
classical monocyte: 3.2 nTPM
myeloid DC: 2.6 nTPM
neutrophil: 2.4 nTPM
non-classical monocyte: 1.4 nTPM
total PBMC: 0.9 nTPM

Brain region

choroid plexus: 48 nTPM
medulla oblongata: 28 nTPM
white matter: 27 nTPM
midbrain: 26 nTPM
thalamus: 24 nTPM
basal ganglia: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: 0.49
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM114A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RAB2B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM114A1 as an antibody target. Whether an autoantibody or antibody against FAM114A1 could matter depends on whether native FAM114A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM114A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM114A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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