Seroatlas · Human Serome Atlas

PZP

Pregnancy zone protein

Also known as: CPAMD6, PZP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P20742
Gene: PZP
Ensembl: ENSG00000126838
Chromosome: 12
Canonical length: 1482 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homotetramer

OverviewNCBI Gene

The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

1482 residues, UniProt reviewed canonical sequence.

>P20742|PZP
     1  MRKDRLLHLC LVLLLILLSA SDSNSTEPQY MVLVPSLLHT EAPKKGCVLL SHLNETVTVS
    61  ASLESGRENR SLFTDLVAEK DLFHCVSFTL PRISASSEVA FLSIQIKGPT QDFRKRNTVL
   121  VLNTQSLVFV QTDKPMYKPG QTVRFRVVSV DENFRPRNEL IPLIYLENPR RNRIAQWQSL
   181  KLEAGINQLS FPLSSEPIQG SYRVVVQTES GGRIQHPFTV EEFVLPKFEV KVQVPKIISI
   241  MDEKVNITVC GEYTYGKPVP GLATVSLCRK LSRVLNCDKQ EVCEEFSQQL NSNGCITQQV
   301  HTKMLQITNT GFEMKLRVEA RIREEGTDLE VTANRISEIT NIVSKLKFVK VDSHFRQGIP
   361  FFAQVLLVDG KGVPIPNKLF FISVNDANYY SNATTNEQGL AQFSINTTSI SVNKLFVRVF
   421  TVHPNLCFHY SWVAEDHQGA QHTANRVFSL SGSYIHLEPV AGTLPCGHTE TITAHYTLNR
   481  QAMGELSELS FHYLIMAKGV IVRSGTHTLP VESGDMKGSF ALSFPVESDV APIARMFIFA
   541  ILPDGEVVGD SEKFEIENCL ANKVDLSFSP AQSPPASHAH LQVAAAPQSL CALRAVDQSV
   601  LLMKPEAELS VSSVYNLLTV KDLTNFPDNV DQQEEEQGHC PRPFFIHNGA IYVPLSSNEA
   661  DIYSFLKGMG LKVFTNSKIR KPKSCSVIPS VSAGAVGQGY YGAGLGVVER PYVPQLGTYN
   721  VIPLNNEQSS GPVPETVRSY FPETWIWELV AVNSSGVAEV GVTVPDTITE WKAGAFCLSE
   781  DAGLGISSTA SLRAFQPFFV ELTMPYSVIR GEVFTLKATV LNYLPKCIRV SVQLKASPAF
   841  LASQNTKGEE SYCICGNERQ TLSWTVTPKT LGNVNFSVSA EAMQSLELCG NEVVEVPEIK
   901  RKDTVIKTLL VEAEGIEQEK TFSSMTCASG ANVSEQLSLK LPSNVVKESA RASFSVLGDI
   961  LGSAMQNIQN LLQMPYGCGE QNMVLFAPNI YVLNYLNETQ QLTQEIKAKA VGYLITGYQR
  1021  QLNYKHQDGS YSTFGERYGR NQGNTWLTAF VLKTFAQARS YIFIDEAHIT QSLTWLSQMQ
  1081  KDNGCFRSSG SLLNNAIKGG VEDEATLSAY VTIALLEIPL PVTNPIVRNA LFCLESAWNV
  1141  AKEGTHGSHV YTKALLAYAF SLLGKQNQNR EILNSLDKEA VKEDNLVHWE RPQRPKAPVG
  1201  HLYQTQAPSA EVEMTSYVLL AYLTAQPAPT SGDLTSATNI VKWIMKQQNA QGGFSSTQDT
  1261  VVALHALSRY GAATFTRTEK TAQVTVQDSQ TFSTNFQVDN NNLLLLQQIS LPELPGEYVI
  1321  TVTGERCVYL QTSMKYNILP EKEDSPFALK VQTVPQTCDG HKAHTSFQIS LTISYTGNRP
  1381  ASNMVIVDVK MVSGFIPLKP TVKMLERSSS VSRTEVSNNH VLIYVEQVTN QTLSFSFMVL
  1441  QDIPVGDLKP AIVKVYDYYE TDESVVAEYI APCSTDTEHG NV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PZP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

liver: 76 nTPM
testis: 2.1 nTPM
endometrium: 1.2 nTPM
fallopian tube: 1.2 nTPM
basal ganglia: 1.1 nTPM
hypothalamus: 1.1 nTPM

Single-cell type

mast cells: 268 nCPM
cardiomyocytes: 200 nCPM
ependymal cells: 197 nCPM
respiratory ciliated cells: 154 nCPM
myonuclei: 75 nCPM
t-cells: 72 nCPM

Immune cell

gdT-cell: 1.1 nTPM
MAIT T-cell: 1.1 nTPM
memory CD8 T-cell: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
basophil: 0 nTPM

Brain region

midbrain: 14 nTPM
pons: 8.8 nTPM
medulla oblongata: 5.9 nTPM
white matter: 3.5 nTPM
basal ganglia: 3.4 nTPM
hypothalamus: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

female pregnancy

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PZP as an antibody target. Whether an autoantibody or antibody against PZP could matter depends on whether native PZP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PZP is annotated as secreted, so native PZP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PZP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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