Alpha-macroglobulin-like, TED domain

Definition

This entry corresponds to the TED domain of the complement components such as C3, C4 and C5 PMID:34970276. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved [[cite:PMID:10625650], [cite:PMID:11106161], [cite:PMID:11387479], [cite:PMID:10825534]].

11 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (11 proteins: gene, accession, name)

• A2M
• A2ML1
• C3
• C3P1
• C4A
• C4B
• C5
• CD109
• CPAMD8
• OVOS1
• PZP