Alpha-2-macroglobulin, bait region domain

Definition

Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system PMID:34970276. However, A2M-like proteins were identified in pathogenic invasive bacteria and species that colonize higher eukaryotes. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region [[cite:PMID:25221932], [cite:PMID:22290936]]. The bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognised as the Venus flytrap mechanism PMID:25221932.

10 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (10 proteins: gene, accession, name)

• A2M
• A2ML1
• C3
• C4A
• C4B
• C5
• CD109
• CPAMD8
• OVOS1
• PZP