Alpha-2-macroglobulin, TED domain

Definition

This entry represents the TED (thiol ester-containing domain) domain found in alpha2-macroglobulin (alpha(2)-M) and related proteins [[cite:PMID:17608619], [cite:PMID:34970276], [cite:PMID:30690067]]. This domain has a short highly conserved region of proteinase-binding alpha-macro-globulins containing the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved [[cite:PMID:10625650], [cite:PMID:11106161], [cite:PMID:11387479], [cite:PMID:10825534]]. Proteins containing this domain also include pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha(2)-M is a major carrier protein in serum. The structural thioester of alpha(2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha(2)-M and PZP bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZP and alpha(2)-M to the CD91 receptor clearing them from circulation [[cite:PMID:11813239], [cite:PMID:15882859], [cite:PMID:11023837]].

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• A2M
• A2ML1
• CD109
• CPAMD8
• PZP