Seroatlas · Human Serome Atlas

CIDEB

Lipid transferase CIDEB

Also known as: CIDEB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHD4
Gene: CIDEB
Ensembl: ENSG00000136305
Chromosome: 14
Canonical length: 219 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables identical protein binding activity. Involved in lipid droplet fusion and positive regulation of apoptotic process. Acts upstream of or within apoptotic process. Located in cytosol and perinuclear region of cytoplasm. Is active in lipid droplet. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>Q9UHD4|CIDEB
     1  MEYLSALNPS DLLRSVSNIS SEFGRRVWTS APPPQRPFRV CDHKRTIRKG LTAATRQELL
    61  AKALETLLLN GVLTLVLEED GTAVDSEDFF QLLEDDTCLM VLQSGQSWSP TRSGVLSYGL
   121  GRERPKHSKD IARFTFDVYK QNPRDLFGSL NVKATFYGLY SMSCDFQGLG PKKVLRELLR
   181  WTSTLLQGLG HMLLGISSTL RHAVEGAEQW QQKGRLHSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIDEB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 448 nTPM

Expression across tissuesHPA

Tissue

liver: 448 nTPM
duodenum: 176 nTPM
small intestine: 143 nTPM
spleen: 101 nTPM
adrenal gland: 43 nTPM
esophagus: 39 nTPM

Single-cell type

ependymal cells: 4.7 nCPM
enterocytes: 3.9 nCPM
microglia: 3.5 nCPM
hepatocytes: 3.1 nCPM
innate lymphoid cells: 2.2 nCPM
papillary tip epithelial cells: 1.8 nCPM

Immune cell

NK-cell: 8.6 nTPM
eosinophil: 7.9 nTPM
myeloid DC: 7.6 nTPM
classical monocyte: 7.1 nTPM
neutrophil: 4.9 nTPM
gdT-cell: 4.6 nTPM

Brain region

hypothalamus: 5.2 nTPM
cerebellum: 3.4 nTPM
choroid plexus: 3.4 nTPM
midbrain: 3.2 nTPM
thalamus: 3 nTPM
medulla oblongata: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: 0.12
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CIDEB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIDEB as an antibody target. Whether an autoantibody or antibody against CIDEB could matter depends on whether native CIDEB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIDEB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIDEB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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