PRDX6

Protein identityUniProt · HPA

UniProt accession

P30041

Gene

PRDX6

Ensembl

ENSG00000117592

Chromosome

1

Canonical length

224 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>P30041|PRDX6
     1  MPGGLLLGDV APNFEANTTV GRIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE
    61  FAKRNVKLIA LSIDSVEDHL AWSKDINAYN CEEPTEKLPF PIIDDRNREL AILLGMLDPA
   121  EKDEKGMPVT ARVVFVFGPD KKLKLSILYP ATTGRNFDEI LRVVISLQLT AEKRVATPVD
   181  WKDGDSVMVL PTIPEEEAKK LFPKGVFTKE LPSGKKYLRY TPQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRDX6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

566 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRDX6.

Disease | ImmuneIEDB

Conditions an epitope on PRDX6 was assayed in.

• urinary bladder cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.6

gnomAD pLI

0

gnomAD missense Z

1.47

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell redox homeostasis
• cellular oxidant detoxification
• glycerophospholipid catabolic process
• hydrogen peroxide catabolic process
• positive regulation of mRNA splicing, via spliceosome
• response to oxidative stress

Molecular functions

• 1-acylglycerophosphocholine O-acyltransferase activity
• cadherin binding
• calcium-independent phospholipase A2 activity
• glutathione peroxidase activity
• identical protein binding
• peroxidase activity
• peroxiredoxin activity
• phospholipase A2 activity
• ubiquitin protein ligase binding

Cellular components

• azurophil granule lumen
• cytoplasm
• cytosol
• extracellular exosome
• extracellular region
• extracellular space
• membrane
• nucleus
• perinuclear region of cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
• Thioredoxin domain
• Peroxiredoxin, C-terminal
• Peroxiredoxin, AhpC-type
• Thioredoxin-like superfamily
• AhpC/TSA family
• C-terminal domain of 1-Cys peroxiredoxin
• 1-Cys peroxiredoxin

KeywordsUniProt

• Acetylation
• Antioxidant
• Cytoplasm
• Hydrolase
• Lipid degradation
• Lipid metabolism
• Lysosome
• Multifunctional enzyme
• Oxidoreductase
• Peroxidase
• Phosphoprotein
• Redox-active center
• Transferase

InteractionsUniProt · HPA

Protein binding partners of PRDX6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• APEX1
• GSTP1
• STH