Seroatlas · Human Serome Atlas

STH

Saitohin

Also known as: MAPTIT, STH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWL8
Gene: STH
Ensembl: ENSG00000256762
Chromosome: 17
Canonical length: 128 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Involved in positive regulation of mRNA splicing, via spliceosome. Located in several cellular components, including Golgi apparatus; nucleoplasm; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>Q8IWL8|STH
     1  MSEGGGQVSC IFAAPTRLCR WPALIECGVN LTQPLCEWMI QVARDRTLSL AWEVASLLTL
    61  SSSEVGLEGV GTIWPSSYSS EESSRNGAEQ GRQLSIEGPF QGQNCPSHPA AALPLPMRGE
   121  SQATSCQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 1.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 1.1 nTPM
cerebral cortex: 0.7 nTPM
skeletal muscle: 0.6 nTPM
retina: 0.4 nTPM
basal ganglia: 0.3 nTPM
breast: 0.3 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 19 nTPM
cerebellum: 17 nTPM
basal ganglia: 15 nTPM
cerebral cortex: 15 nTPM
thalamus: 13 nTPM
hippocampal formation: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.14
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

via spliceosome
positive regulation of mRNA splicing

Cellular components

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PRDX6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STH as an antibody target. Whether an autoantibody or antibody against STH could matter depends on whether native STH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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