Seroatlas · Human Serome Atlas

PPP1R1A

Protein phosphatase 1 regulatory subunit 1A

Also known as: PPR1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13522
Gene: PPP1R1A
Ensembl: ENSG00000135447
Chromosome: 12
Canonical length: 171 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

171 residues, UniProt reviewed canonical sequence.

>Q13522|PPP1R1A
     1  MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI DEDRIPNPHL
    61  KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE PEGAAESTGT QESRPPGIPD
   121  TEVESRLGTS GTAKKTAECI PKTHERGSKE PSTKEPSTHI PPLDSKGANS V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 780 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 780 nTPM
tongue: 253 nTPM
adipose tissue: 227 nTPM
kidney: 211 nTPM
basal ganglia: 183 nTPM
breast: 173 nTPM

Single-cell type

hepatocytes: 259 nCPM
pancreatic islet cells: 210 nCPM
granulosa cells: 75 nCPM
epididymal efferent duct absorptive cells: 45 nCPM
retinal horizontal cells: 42 nCPM
smooth muscle cells: 37 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 115 nTPM
cerebral cortex: 66 nTPM
hippocampal formation: 41 nTPM
hypothalamus: 39 nTPM
amygdala: 38 nTPM
white matter: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0.02
gnomAD missense Z: 0.98
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein serine/threonine phosphatase inhibitor activity

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PPP1R15A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R1A as an antibody target. Whether an autoantibody or antibody against PPP1R1A could matter depends on whether native PPP1R1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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