Seroatlas · Human Serome Atlas

PAK6

Serine/threonine-protein kinase PAK 6

Also known as: PAK5, PAK6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQU5
Gene
PAK6
Ensembl
ENSG00000137843
Chromosome
15
Canonical length
681 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Cell Junctions

OverviewNCBI Gene

This gene represents readthrough transcription between the genes BUB1B (mitotic checkpoint serine/threonine-protein kinase BUB1 beta) and PAK6 (serine/threonine-protein kinase PAK 6). The protein encoded by the readthrough transcripts is the same as the product of the downstream gene (PAK6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

681 residues, UniProt reviewed canonical sequence.

>Q9NQU5|PAK6
     1  MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP KPVVDPSRIT
    61  RVQLQPMKTV VRGSAMPVDG YISGLLNDIQ KLSVISSNTL RGRSPTSRRR AQSLGLLGDE
   121  HWATDPDMYL QSPQSERTDP HGLYLSCNGG TPAGHKQMPW PEPQSPRVLP NGLAAKAQSL
   181  GPAEFQGASQ RCLQLGACLQ SSPPGASPPT GTNRHGMKAA KHGSEEARPQ SCLVGSATGR
   241  PGGEGSPSPK TRESSLKRRL FRSMFLSTAA TAPPSSSKPG PPPQSKPNSS FRPPQKDNPP
   301  SLVAKAQSLP SDQPVGTFSP LTTSDTSSPQ KSLRTAPATG QLPGRSSPAG SPRTWHAQIS
   361  TSNLYLPQDP TVAKGALAGE DTGVVTHEQF KAALRMVVDQ GDPRLLLDSY VKIGEGSTGI
   421  VCLAREKHSG RQVAVKMMDL RKQQRRELLF NEVVIMRDYQ HFNVVEMYKS YLVGEELWVL
   481  MEFLQGGALT DIVSQVRLNE EQIATVCEAV LQALAYLHAQ GVIHRDIKSD SILLTLDGRV
   541  KLSDFGFCAQ ISKDVPKRKS LVGTPYWMAP EVISRSLYAT EVDIWSLGIM VIEMVDGEPP
   601  YFSDSPVQAM KRLRDSPPPK LKNSHKVSPV LRDFLERMLV RDPQERATAQ ELLDHPFLLQ
   661  TGLPECLVPL IQLYRKQTST C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAK6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 31 nTPM
  • skin: 27 nTPM
  • esophagus: 25 nTPM
  • basal ganglia: 23 nTPM
  • amygdala: 23 nTPM
  • cerebellum: 20 nTPM

Single-cell type

  • cytotrophoblasts: 68 nCPM
  • esophageal suprabasal cells: 43 nCPM
  • migrating cytotrophoblasts: 36 nCPM
  • esophageal basal cells: 34 nCPM
  • esophageal apical cells: 32 nCPM
  • suprabasal keratinocytes: 23 nCPM

Immune cell

  • gdT-cell: 2.3 nTPM
  • memory CD8 T-cell: 1.9 nTPM
  • basophil: 1.2 nTPM
  • eosinophil: 1.2 nTPM
  • NK-cell: 0.9 nTPM
  • MAIT T-cell: 0.8 nTPM

Brain region

  • cerebral cortex: 52 nTPM
  • basal ganglia: 49 nTPM
  • hippocampal formation: 41 nTPM
  • amygdala: 40 nTPM
  • cerebellum: 33 nTPM
  • white matter: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
0.47
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAK6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAK6 as an antibody target. Whether an autoantibody or antibody against PAK6 could matter depends on whether native PAK6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAK6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAK6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PAK6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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