POU4F2
POU domain, class 4, transcription factor 2
Also known as: Brn-3b, BRN3B, PO4F2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q12837
- Gene
- POU4F2
- Ensembl
- ENSG00000151615
- Chromosome
- 4
- Canonical length
- 409 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011]
Canonical amino-acid sequenceUniProt
409 residues, UniProt reviewed canonical sequence.
>Q12837|POU4F2
1 MMMMSLNSKQ AFSMPHGGSL HVEPKYSALH STSPGSSAPI APSASSPSSS SNAGGGGGGG
61 GGGGGGGGRS SSSSSSGSSG GGGSEAMRRA CLPTPPSNIF GGLDESLLAR AEALAAVDIV
121 SQSKSHHHHP PHHSPFKPDA TYHTMNTIPC TSAASSSSVP ISHPSALAGT HHHHHHHHHH
181 HHQPHQALEG ELLEHLSPGL ALGAMAGPDG AVVSTPAHAP HMATMNPMHQ AALSMAHAHG
241 LPSHMGCMSD VDADPRDLEA FAERFKQRRI KLGVTQADVG SALANLKIPG VGSLSQSTIC
301 RFESLTLSHN NMIALKPILQ AWLEEAEKSH REKLTKPELF NGAEKKRKRT SIAAPEKRSL
361 EAYFAIQPRP SSEKIAAIAE KLDLKKNVVR VWFCNQRQKQ KRMKYSAGILocalizationUniProt · AlphaFold · HPA
Whether an antibody against POU4F2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 1 nTPM
Expression across tissuesHPA
Tissue
- testis: 1 nTPM
- retina: 0.9 nTPM
- midbrain: 0.2 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
Single-cell type
- retinal ganglion cells: 16 nCPM
- late primary spermatocytes: 1.7 nCPM
- granulosa cells: 1.6 nCPM
- brain excitatory neurons: 0.8 nCPM
- late spermatids: 0.3 nCPM
- peritubular myoid cells: 0.2 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 17 nTPM
- pons: 11 nTPM
- medulla oblongata: 6.5 nTPM
- thalamus: 0.5 nTPM
- spinal cord: 0.4 nTPM
- white matter: 0.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.95
- gnomAD pLI
- 0.07
- gnomAD missense Z
- 0.08
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- axon extension
- axon guidance
- cellular response to cytokine stimulus
- cellular response to estradiol stimulus
- cellular response to insulin stimulus
- dorsal root ganglion development
- estrogen receptor signaling pathway
- heart development
- intrinsic apoptotic signaling pathway by p53 class mediator
- MAPK cascade
- negative regulation of adipose tissue development
- negative regulation of amacrine cell differentiation
- negative regulation of cell differentiation
- negative regulation of DNA-binding transcription factor activity
- negative regulation of transcription by RNA polymerase II
- neuromuscular process controlling balance
- neuron differentiation
- positive regulation of axon extension
- positive regulation of cell differentiation
- positive regulation of D-glucose import
- positive regulation of osteoclast differentiation
- positive regulation of programmed cell death
- positive regulation of transcription by RNA polymerase II
- positive regulation of transcription regulatory region DNA binding
- regulation of DNA-binding transcription factor activity
- regulation of transcription by RNA polymerase II
- retina development in camera-type eye
- retinal ganglion cell axon guidance
- sensory perception of sound
- regulation of retinal ganglion cell axon guidance
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- p53 binding
- promoter-specific chromatin binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of POU4F2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads POU4F2 as an antibody target. Whether an autoantibody or antibody against POU4F2 could matter depends on whether native POU4F2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
POU4F2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label POU4F2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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