DLX2

Protein identityUniProt · HPA

UniProt accession

Q07687

Gene

DLX2

Ensembl

ENSG00000115844

Chromosome

2

Canonical length

328 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nuclear speckles

OverviewNCBI Gene

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>Q07687|DLX2
     1  MTGVFDSLVA DMHSTQIAAS STYHQHQQPP SGGGAGPGGN SSSSSSLHKP QESPTLPVST
    61  ATDSSYYTNQ QHPAGGGGGG GSPYAHMGSY QYQASGLNNV PYSAKSSYDL GYTAAYTSYA
   121  PYGTSSSPAN NEPEKEDLEP EIRIVNGKPK KVRKPRTIYS SFQLAALQRR FQKTQYLALP
   181  ERAELAASLG LTQTQVKIWF QNRRSKFKKM WKSGEIPSEQ HPGASASPPC ASPPVSAPAS
   241  WDFGVPQRMA GGGGPGSGGS GAGSSGSSPS SAASAFLGNY PWYHQTSGSA SHLQATAPLL
   301  HPTQTPQPHH HHHHHGGGGA PVSAGTIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

2.9 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.25

gnomAD pLI

0.98

gnomAD missense Z

0.95

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• brain development
• branching morphogenesis of a nerve
• cartilage development
• cell differentiation
• cerebral cortex GABAergic interneuron fate commitment
• embryonic cranial skeleton morphogenesis
• embryonic skeletal system development
• forebrain neuron fate commitment
• hippocampus development
• negative regulation of Notch signaling pathway
• negative regulation of oligodendrocyte differentiation
• negative regulation of photoreceptor cell differentiation
• negative regulation of transcription by RNA polymerase II
• neuroblast differentiation
• Notch signaling pathway
• odontogenesis of dentin-containing tooth
• olfactory bulb development
• oligodendrocyte differentiation
• positive regulation of amacrine cell differentiation
• positive regulation of cell differentiation
• positive regulation of transcription by RNA polymerase II
• proximal/distal pattern formation
• regulation of transcription by RNA polymerase II
• subpallium development

Molecular functions

• chromatin binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• single-stranded RNA binding
• transcription cis-regulatory region binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Helix-turn-helix motif
• Homeodomain
• Homedomain-like superfamily
• Homeobox, conserved site
• Homeodomain, metazoa
• Distal-less-like homeobox protein, N-terminal domain
• Distal-less homeobox transcription factors
• Homeodomain
• Homeobox protein distal-less-like N terminal

KeywordsUniProt

• Activator
• Developmental protein
• Differentiation
• DNA-binding
• Homeobox
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of DLX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• POU4F2