Seroatlas · Human Serome Atlas

SSBP1

Single-stranded DNA-binding protein, mitochondrial

Also known as: mtSSB, SSBP, SSBP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q04837
Gene: SSBP1
Ensembl: ENSG00000106028
Chromosome: 7
Canonical length: 148 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Mitochondria,Calyx,Principal piece
Quaternary structure: Homotetramer

OverviewNCBI Gene

SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>Q04837|SSBP1
     1  MFRRPVLQVL RQFVRHESET TTSLVLERSL NRVHLLGRVG QDPVLRQVEG KNPVTIFSLA
    61  TNEMWRSGDS EVYQLGDVSQ KTTWHRISVF RPGLRDVAYQ YVKKGSRIYL EGKIDYGEYM
   121  DKNNVRRQAT TIIADNIIFL SDQTKEKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 139 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 139 nTPM
heart muscle: 132 nTPM
esophagus: 124 nTPM
liver: 113 nTPM
blood vessel: 110 nTPM
tonsil: 106 nTPM

Single-cell type

esophageal suprabasal cells: 526 nCPM
gastric progenitor cells: 492 nCPM
esophageal basal cells: 485 nCPM
late primary spermatocytes: 411 nCPM
migrating cytotrophoblasts: 406 nCPM
cytotrophoblasts: 365 nCPM

Immune cell

basophil: 136 nTPM
T-reg: 124 nTPM
total PBMC: 116 nTPM
memory CD4 T-cell: 114 nTPM
naive CD8 T-cell: 114 nTPM
MAIT T-cell: 108 nTPM

Brain region

hypothalamus: 42 nTPM
midbrain: 41 nTPM
cerebral cortex: 40 nTPM
white matter: 40 nTPM
pons: 38 nTPM
spinal cord: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SSBP1.

Disease | AllUniProt

Conditions SSBP1 is implicated in, by any mechanism.

Optic atrophy 13 with retinal and foveal abnormalities (OPA13) MIM:165510

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 34 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Optic atrophy 13 with retinal and foveal abnormalities
Cone-rod dystrophy
Retinal disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 1.11
DepMap mean gene effect: -0.36
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleic acid-binding, OB-fold
Primosome PriB/single-strand DNA-binding
Single-stranded DNA-binding protein
Single-strand binding protein family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SSBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSBP1 as an antibody target. Whether an autoantibody or antibody against SSBP1 could matter depends on whether native SSBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SSBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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