PTPN14

Protein identityUniProt · HPA

UniProt accession

Q15678

Gene

PTPN14

Ensembl

ENSG00000152104

Chromosome

1

Canonical length

1187 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

1187 residues, UniProt reviewed canonical sequence.

>Q15678|PTPN14
     1  MPFGLKLRRT RRYNVLSKNC FVTRIRLLDS NVIECTLSVE STGQECLEAV AQRLELRETH
    61  YFGLWFLSKS QQARWVELEK PLKKHLDKFA NEPLLFFGVM FYVPNVSWLQ QEATRYQYYL
   121  QVKKDVLEGR LRCTLDQVIR LAGLAVQADF GDYNQFDSQD FLREYVLFPM DLALEEAVLE
   181  ELTQKVAQEH KAHSGILPAE AELMYINEVE RLDGFGQEIF PVKDNHGNCV HLGIFFMGIF
   241  VRNRIGRQAV IYRWNDMGNI THNKSTILVE LINKEETALF HTDDIENAKY ISRLFATRHK
   301  FYKQNKICTE QSNSPPPIRR QPTWSRSSLP RQQPYILPPV HVQCGEHYSE THTSQDSIFH
   361  GNEEALYCNS HNSLDLNYLN GTVTNGSVCS VHSVNSLNCS QSFIQASPVS SNLSIPGSDI
   421  MRADYIPSHR HSAIIVPSYR PTPDYETVMR QMKRGILHTD SQSQSLRNLN IINTHAYNQP
   481  EDLVYSQPEM RERHPYTVPY GPQGVYSNKL VSPSDQRNPK NNVVPSKPGA SAISHTVSTP
   541  ELANMQLQGS HNYSTAHMLK NYLFRPPPPY PRPRPATSTP DLASHRHKYV SGSSPDLVTR
   601  KVQLSVKTFQ EDSSPVVHQS LQEVSEPLTA TKHHGTVNKR HSLEVMNSMV RGMEAMTLKS
   661  LHLPMARRNT LREQGPPEEG SGSHEVPQLP QYHHKKTFSD ATMLIHSSES EEEEEEAPES
   721  VPQIPMLREK MEYSAQLQAA LARIPNKPPP EYPGPRKSVS NGALRQDQAS LPPAMARARV
   781  LRHGPAKAIS MSRTDPPAVN GASLGPSISE PDLTSVKERV KKEPVKERPV SEMFSLEDSI
   841  IEREMMIRNL EKQKMAGLEA QKRPLMLAAL NGLSVARVSG REENRVDATR VPMDERFRTL
   901  KKKLEEGMVF TEYEQIPKKK ANGIFSTAAL PENAERSRIR EVVPYEENRV ELIPTKENNT
   961  GYINASHIKV VVGGAEWHYI ATQGPLPHTC HDFWQMVWEQ GVNVIAMVTA EEEGGRTKSH
  1021  RYWPKLGSKH SSATYGKFKV TTKFRTDSVC YATTGLKVKH LLSGQERTVW HLQYTDWPDH
  1081  GCPEDVQGFL SYLEEIQSVR RHTNSMLEGT KNRHPPIVVH CSAGVGRTGV LILSELMIYC
  1141  LEHNEKVEVP MMLRLLREQR MFMIQTIAQY KFVYQVLIQF LQNSRLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTPN14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

18 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTPN14.

Disease | AllUniProt

Conditions PTPN14 is implicated in, by any mechanism.

• Choanal atresia and lymphedema (CATLPH) MIM:613611

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 277 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Lymphedema-posterior choanal atresia syndrome
• Esophageal atresia/tracheoesophageal fistula

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.37

gnomAD pLI

0.22

gnomAD missense Z

1.68

DepMap mean gene effect

0.13

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• lymphangiogenesis
• negative regulation of cell population proliferation
• protein dephosphorylation
• regulation of protein export from nucleus

Molecular functions

• protein tyrosine phosphatase activity
• receptor tyrosine kinase binding
• transcription coregulator activity

Cellular components

• cytoplasm
• cytoskeleton
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Tyrosine-specific protein phosphatase, PTPase domain
• FERM domain
• Tyrosine-specific protein phosphatases domain
• Protein-tyrosine phosphatase, catalytic
• PH-like domain superfamily
• FERM/acyl-CoA-binding protein superfamily
• Protein-tyrosine phosphatase, non-receptor type-14/21
• Protein-tyrosine phosphatase, active site
• FERM, N-terminal
• FERM, C-terminal PH-like domain
• FERM conserved site
• FERM central domain
• Band 4.1 domain
• Protein-tyrosine phosphatase-like
• Ubiquitin-like domain superfamily
• FERM superfamily, second domain
• PTPN14/21, FERM domain C-lobe
• Protein-tyrosine phosphatase
• FERM central domain
• FERM N-terminal domain
• FERM C-terminal PH-like domain

KeywordsUniProt

• Cytoplasm
• Cytoskeleton
• Hydrolase
• Nucleus
• Phosphoprotein
• Protein phosphatase
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of PTPN14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FLT4
• MAGI1
• PDLIM7
• YAP1
• YWHAG