Seroatlas · Human Serome Atlas

TPM2

Tropomyosin beta chain

Also known as: AMCD1, DA1, NEM4, TPM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07951
Gene
TPM2
Ensembl
ENSG00000198467
Chromosome
9
Canonical length
284 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

284 residues, UniProt reviewed canonical sequence.

>P07951|TPM2
     1  MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL KGTEDEVEKY
    61  SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA
   121  DESERGMKVI ENRAMKDEEK MELQEMQLKE AKHIAEDSDR KYEEVARKLV ILEGELERSE
   181  ERAEVAESKC GDLEEELKIV TNNLKSLEAQ ADKYSTKEDK YEEEIKLLEE KLKEAETRAE
   241  FAERSVAKLE KTIDDLEDEV YAQKMKYKAI SEELDNALND ITSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
36,557 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 36,557 nTPM
  • tongue: 15,657 nTPM
  • blood vessel: 6,564 nTPM
  • colon: 4,777 nTPM
  • urinary bladder: 2,493 nTPM
  • endometrium: 2,419 nTPM

Single-cell type

  • smooth muscle cells: 8,892 nCPM
  • vascular smooth muscle cells: 5,606 nCPM
  • breast myoepithelial cells: 4,191 nCPM
  • hepatic stellate cells: 2,601 nCPM
  • decidual stromal cells: 2,342 nCPM
  • salivary myoepithelial cells: 2,135 nCPM

Immune cell

  • plasmacytoid DC: 400 nTPM
  • total PBMC: 2.1 nTPM
  • MAIT T-cell: 0.4 nTPM
  • myeloid DC: 0.4 nTPM
  • neutrophil: 0.4 nTPM
  • memory CD8 T-cell: 0.3 nTPM

Brain region

  • choroid plexus: 126 nTPM
  • cerebral cortex: 64 nTPM
  • cerebellum: 50 nTPM
  • basal ganglia: 44 nTPM
  • amygdala: 40 nTPM
  • medulla oblongata: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TPM2.

Disease | AllUniProt

Conditions TPM2 is implicated in, by any mechanism.

Disease | GeneticClinVar

44 pathogenic / likely-pathogenic of 381 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Arthrogryposis, distal, type 1A
  • Congenital myopathy 23
  • Arthrogryposis, distal, type 2B4
  • TPM2-related disorder
  • Inborn genetic diseases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
2.13
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TPM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPM2 as an antibody target. Whether an autoantibody or antibody against TPM2 could matter depends on whether native TPM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TPM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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