Seroatlas · Human Serome Atlas

PAGR1

PAXIP1-associated glutamate-rich protein 1

Also known as: C16orf53, GAS, MGC4606, PA1, PAGR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTK6
Gene: PAGR1
Ensembl: ENSG00000280789
Chromosome: 16
Canonical length: 254 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables nuclear estrogen receptor binding activity. Involved in positive regulation of cell cycle G1/S phase transition; positive regulation of intracellular estrogen receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of MLL3/4 complex. Biomarker of esophagus squamous cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q9BTK6|PAGR1
     1  MSLARGHGDT AASTAAPLSE EGEVTSGLQA LAVEDTGGPS ASAGKAEDEG EGGREETERE
    61  GSGGEEAQGE VPSAGGEEPA EEDSEDWCVP CSDEEVELPA DGQPWMPPPS EIQRLYELLA
   121  AHGTLELQAE ILPRRPPTPE AQSEEERSDE EPEAKEEEEE KPHMPTEFDF DDEPVTPKDS
   181  LIDRRRTPGS SARSQKREAR LDKVLSDMKR HKKLEEQILR TGRDLFSLDS EDPSPASPPL
   241  RSSGSSLFPR QRKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAGR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 54 nTPM
ovary: 33 nTPM
pituitary gland: 23 nTPM
cervix: 21 nTPM
vagina: 15 nTPM
endometrium: 14 nTPM

Single-cell type

epicardial cells: 18 nCPM
astrocytes: 2.2 nCPM
ependymal cells: 2.2 nCPM
bergmann glia: 1.6 nCPM
brain excitatory neurons: 1.4 nCPM
gastric chief cells: 1.1 nCPM

Immune cell

eosinophil: 33 nTPM
basophil: 23 nTPM
MAIT T-cell: 22 nTPM
naive CD4 T-cell: 22 nTPM
plasmacytoid DC: 22 nTPM
myeloid DC: 21 nTPM

Brain region

cerebellum: 29 nTPM
white matter: 16 nTPM
cerebral cortex: 14 nTPM
medulla oblongata: 14 nTPM
midbrain: 13 nTPM
pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.74
gnomAD missense Z: 0.63
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

nuclear estrogen receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

PTIP-associated protein 1
PAXIP1-associated-protein-1 C term PTIP binding protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAGR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAGR1 as an antibody target. Whether an autoantibody or antibody against PAGR1 could matter depends on whether native PAGR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAGR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAGR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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