Seroatlas · Human Serome Atlas

PARP10

Protein mono-ADP-ribosyltransferase PARP10

Also known as: ARTD10, FLJ14464, PAR10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53GL7
Gene: PARP10
Ensembl: ENSG00000178685
Chromosome: 8
Canonical length: 1025 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoli rim,Golgi apparatus,Cytosol

OverviewNCBI Gene

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1025 residues, UniProt reviewed canonical sequence.

>Q53GL7|PARP10
     1  MVAMAEAEAG VAVEVRGLPP AVPDELLTLY FENRRRSGGG PVLSWQRLGC GGVLTFREPA
    61  DAERVLAQAD HELHGAQLSL RPAPPRAPAR LLLQGLPPGT TPQRLEQHVQ ALLRASGLPV
   121  QPCCALASPR PDRALVQLPK PLSEADVRVL EEQAQNLGLE GTLVSLARVP QARAVRVVGD
   181  GASVDLLLLE LYLENERRSG GGPLEDLQRL PGPLGTVASF QQWQVAERVL QQEHRLQGSE
   241  LSLVPHYDIL EPEELAENTS GGDHPSTQGP RATKHALLRT GGLVTALQGA GTVTMGSGEE
   301  PGQSGASLRT GPMVQGRGIM TTGSGQEPGQ SGTSLRTGPM GSLGQAEQVS SMPMGSLEHE
   361  GLVSLRPVGL QEQEGPMSLG PVGSAGPVET SKGLLGQEGL VEIAMDSPEQ EGLVGPMEIT
   421  MGSLEKAGPV SPGCVKLAGQ EGLVEMVLLM EPGAMRFLQL YHEDLLAGLG DVALLPLEGP
   481  DMTGFRLCGA QASCQAAEEF LRSLLGSISC HVLCLEHPGS ARFLLGPEGQ HLLQGLEAQF
   541  QCVFGTERLA TATLDTGLEE VDPTEALPVL PGNAHTLWTP DSTGGDQEDV SLEEVRELLA
   601  TLEGLDLDGE DWLPRELEEE GPQEQPEEEV TPGHEEEEPV APSTVAPRWL EEEAALQLAL
   661  HRSLEPQGQV AEQEEAAALR QALTLSLLEQ PPLEAEEPPD GGTDGKAQLV VHSAFEQDVE
   721  ELDRALRAAL EVHVQEETVG PWRRTLPAEL RARLERCHGV SVALRGDCTI LRGFGAHPAR
   781  AARHLVALLA GPWDQSLAFP LAASGPTLAG QTLKGPWNNL ERLAENTGEF QEVVRAFYDT
   841  LDAARSSIRV VRVERVSHPL LQQQYELYRE RLLQRCERRP VEQVLYHGTT APAVPDICAH
   901  GFNRSFCGRN ATVYGKGVYF ARRASLSVQD RYSPPNADGH KAVFVARVLT GDYGQGRRGL
   961  RAPPLRGPGH VLLRYDSAVD CICQPSIFVI FHDTQALPTH LITCEHVPRA SPDDPSGLPG
  1021  RSPDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

spleen: 55 nTPM
liver: 36 nTPM
salivary gland: 36 nTPM
kidney: 36 nTPM
ovary: 35 nTPM
appendix: 34 nTPM

Single-cell type

adipocytes: 171 nCPM
cardiomyocytes: 153 nCPM
early primary spermatocytes: 95 nCPM
epicardial cells: 89 nCPM
proximal tubule cells: 88 nCPM
pdcs: 62 nCPM

Immune cell

plasmacytoid DC: 17 nTPM
gdT-cell: 4.4 nTPM
eosinophil: 3.6 nTPM
memory CD8 T-cell: 3.6 nTPM
total PBMC: 3.5 nTPM
intermediate monocyte: 2.8 nTPM

Brain region

medulla oblongata: 32 nTPM
spinal cord: 26 nTPM
pons: 25 nTPM
thalamus: 25 nTPM
white matter: 24 nTPM
cerebral cortex: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PARP10.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 218 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Developmental delay

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 1.55
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Poly(ADP-ribose) polymerase, catalytic domain
Nucleotide-binding alpha-beta plait domain superfamily
Mono-ADP-ribosyltransferase ARTD/PARP
Poly(ADP-ribose) polymerase catalytic domain
PARP14, third RRM domain
PARP-10, RNA recognition motif 1 and 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARP10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARP10 as an antibody target. Whether an autoantibody or antibody against PARP10 could matter depends on whether native PARP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARP10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PARP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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