Seroatlas · Human Serome Atlas

OSBP2

Oxysterol-binding protein 2

Also known as: KIAA1664, ORP-4, ORP4, OSBP2_HUMAN, OSBPL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969R2
Gene: OSBP2
Ensembl: ENSG00000184792
Chromosome: 22
Canonical length: 916 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

916 residues, UniProt reviewed canonical sequence.

>Q969R2|OSBP2
     1  MGKAAAPSRG GGCGGRSRGL SSLFTVVPCL SCHTAAPGMS ASTSGSGPEP KPQPQPVPEP
    61  ERGPLSEQVS EAVSEAVPRS EPVSETTSEP EPGAGQPSEL LQGSRPGSES SSGVGAGPFT
   121  KAASEPLSRA VGSATFLRPE SGSLPALKPL PLLRPGQAKT PLGVPMSGTG TTSSAPLALL
   181  PLDSFEGWLL KWTNYLKGYQ RRWFVLGNGL LSYYRNQGEM AHTCRGTINL STAHIDTEDS
   241  CGILLTSGAR SYHLKASSEV DRQQWITALE LAKAKAVRVM NTHSDDSGDD DEATTPADKS
   301  ELHHTLKNLS LKLDDLSTCN DLIAKHGAAL QRSLTELDGL KIPSESGEKL KVVNERATLF
   361  RITSNAMINA CRDFLELAEI HSRKWQRALQ YEQEQRVHLE ETIEQLAKQH NSLERAFHSA
   421  PGRPANPSKS FIEGSLLTPK GEDSEEDEDT EYFDAMEDST SFITVITEAK EDSRKAEGST
   481  GTSSVDWSSA DNVLDGASLV PKGSSKVKRR VRIPNKPNYS LNLWSIMKNC IGRELSRIPM
   541  PVNFNEPLSM LQRLTEDLEY HHLLDKAVHC TSSVEQMCLV AAFSVSSYST TVHRIAKPFN
   601  PMLGETFELD RLDDMGLRSL CEQVSHHPPS AAHYVFSKHG WSLWQEITIS SKFRGKYISI
   661  MPLGAIHLEF QASGNHYVWR KSTSTVHNII VGKLWIDQSG DIEIVNHKTN DRCQLKFLPY
   721  SYFSKEAARK VTGVVSDSQG KAHYVLSGSW DEQMECSKVM HSSPSSPSSD GKQKTVYQTL
   781  SAKLLWKKYP LPENAENMYY FSELALTLNE HEEGVAPTDS RLRPDQRLME KGRWDEANTE
   841  KQRLEEKQRL SRRRRLEACG PGSSCSSEEE KEADAYTPLW FEKRLDPLTG EMACVYKGGY
   901  WEAKEKQDWH MCPNIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 149 nTPM

Expression across tissuesHPA

Tissue

retina: 149 nTPM
bone marrow: 50 nTPM
testis: 27 nTPM
cerebellum: 22 nTPM
pituitary gland: 20 nTPM
cerebral cortex: 16 nTPM

Single-cell type

rod photoreceptor cells: 1,448 nCPM
late spermatids: 614 nCPM
early spermatids: 324 nCPM
oligodendrocytes: 283 nCPM
retinal bipolar cells: 258 nCPM
brain inhibitory neurons: 242 nCPM

Immune cell

total PBMC: 2 nTPM
intermediate monocyte: 1.1 nTPM
naive CD8 T-cell: 1.1 nTPM
MAIT T-cell: 1 nTPM
memory CD4 T-cell: 1 nTPM
naive CD4 T-cell: 1 nTPM

Brain region

thalamus: 70 nTPM
cerebral cortex: 68 nTPM
cerebellum: 60 nTPM
basal ganglia: 55 nTPM
white matter: 55 nTPM
midbrain: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0
gnomAD missense Z: 1.86
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cholesterol binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OSBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSBP2 as an antibody target. Whether an autoantibody or antibody against OSBP2 could matter depends on whether native OSBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OSBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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