Seroatlas · Human Serome Atlas

PIERCE1

Piercer of microtubule wall 1 protein

Also known as: C9orf116, MGC29761, PIRC1_HUMAN, RbEST47

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5BN46
Gene: PIERCE1
Ensembl: ENSG00000160345
Chromosome: 9
Canonical length: 136 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol,Mid piece

OverviewNCBI Gene

Predicted to be involved in axoneme assembly; establishment of left/right asymmetry; and flagellated sperm motility. Predicted to act upstream of or within DNA damage response; cellular response to UV-C; and regulation of gene expression. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

136 residues, UniProt reviewed canonical sequence.

>Q5BN46|PIERCE1
     1  MAEECPRACA EPVAPKATAP PERTSDYYRV SADLPGRFNN PGWFRGYRTQ KAVSVYRTSN
    61  QAYGSRAPTV HEMPKVFYPN SNKFSQQLAA GGMFRNNTLN VYLEKSIVTG PDNCITSCDR
   121  LNFHPSYNIN RPSICD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIERCE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 91 nTPM
testis: 60 nTPM
choroid plexus: 58 nTPM
epididymis: 24 nTPM
hippocampal formation: 20 nTPM
hypothalamus: 20 nTPM

Single-cell type

fallopian tube ciliated cells: 828 nCPM
epididymal efferent duct ciliated cells: 811 nCPM
respiratory ciliated cells: 792 nCPM
late spermatids: 686 nCPM
late primary spermatocytes: 533 nCPM
endometrial ciliated cells: 451 nCPM

Immune cell

MAIT T-cell: 1.2 nTPM
classical monocyte: 0.8 nTPM
naive CD4 T-cell: 0.7 nTPM
NK-cell: 0.6 nTPM
gdT-cell: 0.5 nTPM
intermediate monocyte: 0.5 nTPM

Brain region

choroid plexus: 37 nTPM
midbrain: 27 nTPM
medulla oblongata: 19 nTPM
spinal cord: 18 nTPM
hypothalamus: 15 nTPM
hippocampal formation: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIERCE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIERCE1 as an antibody target. Whether an autoantibody or antibody against PIERCE1 could matter depends on whether native PIERCE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIERCE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIERCE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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