Seroatlas · Human Serome Atlas

PIERCE2

Piercer of microtubule wall 2 protein

Also known as: C15orf65, FLJ27352, PIRC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H3BRN8
Gene
PIERCE2
Ensembl
ENSG00000261652
Chromosome
15
Canonical length
121 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in axoneme assembly; determination of left/right symmetry; and flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>H3BRN8|PIERCE2
     1  MTDRNRDKKS TSPSNSDTEM KSEQLPPCVN PGNPVFSCML DPKTLQTATS LSKPQMIMYK
    61  TNSSHYGEFL PIPQFFPCNY TPKEQVFSSH IRATGFYQNN TLNTAPDRTR TLDFPNIQHT
   121  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIERCE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
8.8 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 8.8 nTPM
  • testis: 8.7 nTPM
  • salivary gland: 8.5 nTPM
  • fallopian tube: 7.6 nTPM
  • pancreas: 7.2 nTPM
  • retina: 7.2 nTPM

Single-cell type

  • late primary spermatocytes: 172 nCPM
  • early spermatids: 168 nCPM
  • respiratory ciliated cells: 98 nCPM
  • endometrial ciliated cells: 91 nCPM
  • fallopian tube ciliated cells: 83 nCPM
  • epididymal efferent duct ciliated cells: 83 nCPM

Immune cell

  • basophil: 4.7 nTPM
  • eosinophil: 1.8 nTPM
  • memory B-cell: 0.9 nTPM
  • naive B-cell: 0.8 nTPM
  • neutrophil: 0.8 nTPM
  • intermediate monocyte: 0.7 nTPM

Brain region

  • choroid plexus: 8.2 nTPM
  • medulla oblongata: 4.4 nTPM
  • midbrain: 4.4 nTPM
  • pons: 4.2 nTPM
  • cerebral cortex: 3.4 nTPM
  • spinal cord: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0.26
DepMap mean gene effect
0.14
DepMap dependency class
none

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIERCE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIERCE2 as an antibody target. Whether an autoantibody or antibody against PIERCE2 could matter depends on whether native PIERCE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIERCE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIERCE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PIERCE2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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