Seroatlas · Human Serome Atlas

GGN

Gametogenetin

Also known as: FLJ35713, GGN_HUMAN, MGC33369

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UU5
Gene: GGN
Ensembl: ENSG00000179168
Chromosome: 19
Canonical length: 652 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

652 residues, UniProt reviewed canonical sequence.

>Q86UU5|GGN
     1  MGNLQSEPSA GGGSRKVQPS DRAPDSRRTS LVEPEMTSQA MRLTRGLGVW FPGSATPPGL
    61  MVPREPQASP STLPLTLERP SPVMPPPEEA AAVSAPPPAP AGTLLPGPSK WQKPAGTPVP
   121  RIRRLLEASH RGQGDPPSLR PLKPPPPPRQ LSVKDTVPRA PSQFPPPLET WKPPPPLPSE
   181  RQPADRRITP ALATPASPPT ESQAGPRNQG QTAGRARGGA PPHAGEGEMA QPADSESGLS
   241  LLCKITFKSR PSLAPPAASS SLAAKASLGG GGGGGLFAAS GAISYAEVLK QGPLPPGAAR
   301  PLGEVSRGAQ EAEGGDGDGE GCSGPPSAPA SQARALPPPP YTTFPGSKPK FDWVSAPDGP
   361  ERHFRFNGAG GGIGAPRRRA AALSGPWGSP PPPPEQIHSA PGPRRPAPAL LAPPTFIFPA
   421  PTNGEPMRPG PPGLQELPPL PPPTPPPTLQ PPALQPTPLP VAPPLTPGLG HKESALAPTA
   481  APALPPALAA DQAPAPSPAP APTVAEPSPP VSAPAPAAAP IKTRTRRNKG SRAARGATRK
   541  DGLHGDGPRE RATATVPDSS GGGGGGSGAS QTGAANTRAA RHWLPFQVLN SCPCKCYCHH
   601  QPRHRRLPRN VSAWLSTSTN HLGEPPWVAT IKLSGSLVAK LEHYDLQATH SN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GGN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

testis: 90 nTPM
duodenum: 2.7 nTPM
small intestine: 2.7 nTPM
blood vessel: 2.6 nTPM
cerebral cortex: 2 nTPM
hippocampal formation: 1.7 nTPM

Single-cell type

late spermatids: 1,225 nCPM
late primary spermatocytes: 578 nCPM
early spermatids: 537 nCPM
enterocytes: 21 nCPM
sertoli cells: 5.3 nCPM
peritubular myoid cells: 2.8 nCPM

Immune cell

eosinophil: 0.8 nTPM
non-classical monocyte: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 6.3 nTPM
pons: 6.2 nTPM
cerebellum: 5.9 nTPM
cerebral cortex: 5.8 nTPM
medulla oblongata: 5.6 nTPM
hippocampal formation: 5.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GGN.

Disease | AllUniProt

Conditions GGN is implicated in, by any mechanism.

Spermatogenic failure 69 (SPGF69) MIM:619826

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 134 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 69

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin protein ligase binding

Protein domainsUniProt · Pfam · InterPro

Gametogenetin
Gametogenetin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GGN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GGN as an antibody target. Whether an autoantibody or antibody against GGN could matter depends on whether native GGN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GGN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GGN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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