Seroatlas · Human Serome Atlas

ODC1

Ornithine decarboxylase

Also known as: DCOR_HUMAN, ODC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P11926
Gene
ODC1
Ensembl
ENSG00000115758
Chromosome
2
Canonical length
461 aa
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>P11926|ODC1
     1  MNNFGNEEFD CHFLDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDILK KHLRWLKALP
    61  RVTPFYAVKC NDSKAIVKTL AATGTGFDCA SKTEIQLVQS LGVPPERIIY ANPCKQVSQI
   121  KYAANNGVQM MTFDSEVELM KVARAHPKAK LVLRIATDDS KAVCRLSVKF GATLRTSRLL
   181  LERAKELNID VVGVSFHVGS GCTDPETFVQ AISDARCVFD MGAEVGFSMY LLDIGGGFPG
   241  SEDVKLKFEE ITGVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKIVLKEQ
   301  TGSDDEDESS EQTFMYYVND GVYGSFNCIL YDHAHVKPLL QKRPKPDEKY YSSSIWGPTC
   361  DGLDRIVERC DLPEMHVGDW MLFENMGAYT VAAASTFNGF QRPTIYYVMS GPAWQLMQQF
   421  QNPDFPPEVE EQDASTLPVS CAWESGMKRH RAACASASIN V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ODC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
154 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 154 nTPM
  • bone marrow: 150 nTPM
  • tonsil: 148 nTPM
  • testis: 121 nTPM
  • urinary bladder: 112 nTPM
  • lymph node: 111 nTPM

Single-cell type

  • late spermatids: 1,458 nCPM
  • platelets: 973 nCPM
  • early spermatids: 557 nCPM
  • late primary spermatocytes: 498 nCPM
  • oocytes: 345 nCPM
  • megakaryocytes: 334 nCPM

Immune cell

  • naive B-cell: 17 nTPM
  • memory B-cell: 16 nTPM
  • plasmacytoid DC: 12 nTPM
  • memory CD8 T-cell: 5.4 nTPM
  • T-reg: 4.8 nTPM
  • naive CD8 T-cell: 4.7 nTPM

Brain region

  • choroid plexus: 67 nTPM
  • white matter: 39 nTPM
  • spinal cord: 37 nTPM
  • thalamus: 37 nTPM
  • hypothalamus: 36 nTPM
  • midbrain: 35 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ODC1.

Disease | AllUniProt

Conditions ODC1 is implicated in, by any mechanism.

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 124 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental disorder with alopecia and brain abnormalities

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.17
gnomAD missense Z
1.47
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ODC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ODC1 as an antibody target. Whether an autoantibody or antibody against ODC1 could matter depends on whether native ODC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ODC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ODC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ODC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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