Seroatlas · Human Serome Atlas

FAM171A1

Protein FAM171A1

Also known as: APCN, C10orf38, F1711_HUMAN, FLJ12884

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VUB5
Gene: FAM171A1
Ensembl: ENSG00000148468
Chromosome: 10
Canonical length: 890 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Involved in regulation of cell shape and stress fiber assembly. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

890 residues, UniProt reviewed canonical sequence.

>Q5VUB5|FAM171A1
     1  MSRSATLLLC LLGCHVWKAV TKTLREPGAG AQEVTLKVHI SDASTHQPVA DALIEIFTNQ
    61  ASIASGTSGT DGVAFIKFQY KLGSQLIVTA SKHAYVPNSA PWKPIRLPVF SSLSLGLLPE
   121  RSATLMVYED VVQIVSGFQG ARPQPRVHFQ RRALRLPENT SYSDLTAFLT AASSPSEVDS
   181  FPYLRGLDGN GTGNSTRHDL TPVTAVSVHL LSSNGTPVLV DGPIYVTVPL ATQSSLRHNA
   241  YVAAWRFDQK LGTWLKSGLG LVHQEGSQLT WTYIAPQLGY WVAAMSPPIP GPVVTQDITT
   301  YHTVFLLAIL GGMAFILLVL LCLLLYYCRR KCLKPRQHHR KLQLPAGLES SKRDQSTSMS
   361  HINLLFSRRA SEFPGPLSVT SHGRPEAPGT KELMSGVHLE MMSPGGEGDL HTPMLKLSYS
   421  TSQEFSSREE LLSCKEEDKS QISFDNLTPS GTLGKDYHKS VEVFPLKARK SMEREGYESS
   481  GNDDYRGSYN TVLSQPLFEK QDREGPASTG SKLTIQEHLY PAPSSPEKEQ LLDRRPTECM
   541  MSRSVDHLER PTSFPRPGQL ICCSSVDQVN DSVYRKVLPA LVIPAHYMKL PGDHSYVSQP
   601  LVVPADQQLE IERLQAELSN PHAGIFPHPS SQIQPQPLSS QAISQQHLQD AGTREWSPQN
   661  ASMSESLSIP ASLNDAALAQ MNSEVQLLTE KALMELGGGK PLPHPRAWFV SLDGRSNAHV
   721  RHSYIDLQRA GRNGSNDASL DSGVDMNEPK SARKGRGDAL SLQQNYPPVQ EHQQKEPRAP
   781  DSTAYTQLVY LDDVEQSGSE CGTTVCTPED SALRCLLEGS SRRSGGQLPS LQEETTRRTA
   841  DAPSEPAASP HQRRSAHEEE EDDDDDDQGE DKKSPWQKRE ERPLMAFNIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM171A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 98 nTPM
basal ganglia: 73 nTPM
midbrain: 50 nTPM
hippocampal formation: 50 nTPM
cerebral cortex: 46 nTPM
amygdala: 44 nTPM

Single-cell type

renal connecting tubule cells: 445 nCPM
astrocytes: 414 nCPM
distal convoluted tubule cells: 351 nCPM
cholangiocytes: 282 nCPM
bergmann glia: 252 nCPM
oligodendrocytes: 220 nCPM

Immune cell

naive CD4 T-cell: 4.7 nTPM
MAIT T-cell: 4.4 nTPM
memory CD4 T-cell: 2.5 nTPM
naive CD8 T-cell: 2.4 nTPM
memory CD8 T-cell: 2.2 nTPM
gdT-cell: 1.7 nTPM

Brain region

white matter: 151 nTPM
medulla oblongata: 143 nTPM
basal ganglia: 128 nTPM
cerebellum: 122 nTPM
thalamus: 119 nTPM
hippocampal formation: 119 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.99
gnomAD missense Z: 0.44
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM171A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM171A1 as an antibody target. Whether an autoantibody or antibody against FAM171A1 could matter depends on whether native FAM171A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM171A1 is annotated at the cell surface, where native FAM171A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FAM171A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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