Seroatlas · Human Serome Atlas

ACOT9

Acyl-coenzyme A thioesterase 9, mitochondrial

Also known as: ACATE2, ACOT9_HUMAN, CGI-16, MT-ACT48

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y305
Gene: ACOT9
Ensembl: ENSG00000123130
Chromosome: X
Canonical length: 439 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a mitochondrial acyl-CoA thioesterase of unknown function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>Q9Y305|ACOT9
     1  MRRAALRLCA LGKGQLTPGR GLTQGPQNPK KQGIFHIHEV RDKLREIVGA STNWRDHVKA
    61  MEERKLLHSF LAKSQDGLPP RRMKDSYIEV LLPLGSEPEL REKYLTVQNT VRFGRILEDL
   121  DSLGVLICYM HNKIHSAKMS PLSIVTALVD KIDMCKKSLS PEQDIKFSGH VSWVGKTSME
   181  VKMQMFQLHG DEFCPVLDAT FVMVARDSEN KGPAFVNPLI PESPEEEELF RQGELNKGRR
   241  IAFSSTSLLK MAPSAEERTT IHEMFLSTLD PKTISFRSRV LPSNAVWMEN SKLKSLEICH
   301  PQERNIFNRI FGGFLMRKAY ELAWATACSF GGSRPFVVAV DDIMFQKPVE VGSLLFLSSQ
   361  VCFTQNNYIQ VRVHSEVASL QEKQHTTTNV FHFTFMSEKE VPLVFPKTYG ESMLYLDGQR
   421  HFNSMSGPAT LRKDYLVEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACOT9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 46 nTPM
blood vessel: 30 nTPM
smooth muscle: 30 nTPM
skeletal muscle: 26 nTPM
lung: 25 nTPM
adipose tissue: 23 nTPM

Single-cell type

neutrophils: 213 nCPM
monocytes: 161 nCPM
cdc: 124 nCPM
macrophages: 83 nCPM
alveolar cells type 1: 76 nCPM
epicardial cells: 71 nCPM

Immune cell

non-classical monocyte: 57 nTPM
intermediate monocyte: 44 nTPM
myeloid DC: 32 nTPM
classical monocyte: 30 nTPM
basophil: 25 nTPM
eosinophil: 22 nTPM

Brain region

choroid plexus: 23 nTPM
hypothalamus: 20 nTPM
cerebral cortex: 20 nTPM
pons: 19 nTPM
thalamus: 18 nTPM
medulla oblongata: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACOT9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACOT9 as an antibody target. Whether an autoantibody or antibody against ACOT9 could matter depends on whether native ACOT9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACOT9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACOT9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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