Seroatlas · Human Serome Atlas

MORN4

MORN repeat-containing protein 4

Also known as: bA548K23.4, C10orf83, FLJ25925, MORN4_HUMAN, rtp

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDC4
Gene: MORN4
Ensembl: ENSG00000171160
Chromosome: 10
Canonical length: 146 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in response to axon injury. Located in cytoplasm and filopodium tip. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

146 residues, UniProt reviewed canonical sequence.

>Q8NDC4|MORN4
     1  MTLTKGSFTY SSGEEYRGEW KEGRRHGFGQ LMFADGGTYL GHFENGLFNG FGVLTFSDGS
    61  RYEGEFAQGK FNGVGVFIRY DNMTFEGEFK NGRVDGFGLL TFPDGSHGIP RNEGLFENNK
   121  LLRREKCSAI VQRAQSASKS ARNLTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MORN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 34 nTPM
cerebral cortex: 33 nTPM
basal ganglia: 32 nTPM
amygdala: 27 nTPM
pituitary gland: 25 nTPM
hippocampal formation: 23 nTPM

Single-cell type

choroid plexus epithelial cells: 45 nCPM
brain inhibitory neurons: 42 nCPM
gonadotrophs: 40 nCPM
other brain neurons: 40 nCPM
endometrial luminal cells: 38 nCPM
lactotrophs: 36 nCPM

Immune cell

naive CD4 T-cell: 2.7 nTPM
memory B-cell: 2.5 nTPM
MAIT T-cell: 2.3 nTPM
T-reg: 2.2 nTPM
gdT-cell: 2 nTPM
naive CD8 T-cell: 1.9 nTPM

Brain region

hypothalamus: 49 nTPM
basal ganglia: 38 nTPM
cerebral cortex: 35 nTPM
thalamus: 34 nTPM
midbrain: 34 nTPM
pons: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.55
gnomAD missense Z: 0.34
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

response to axon injury

Cellular components

Protein domainsUniProt · Pfam · InterPro

MORN repeat
MORN repeat
MORN repeat-containing protein 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MORN4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MORN4 as an antibody target. Whether an autoantibody or antibody against MORN4 could matter depends on whether native MORN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MORN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MORN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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