Seroatlas · Human Serome Atlas

CFAP141

Cilia- and flagella-associated protein 141

Also known as: C1orf189, CP141_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VU69
Gene: CFAP141
Ensembl: ENSG00000163263
Chromosome: 1
Canonical length: 101 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

101 residues, UniProt reviewed canonical sequence.

>Q5VU69|CFAP141
     1  MSVEKMTKVE ESFQKAMGLK KTVDRWRNSH THCLWQMALG QRRNPYATLR MQDTMVQELA
    61  LAKKQLLMVR QAALHQLFEK EHQQYQQELN QMGKAFYVER F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP141 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 29 nTPM
testis: 24 nTPM
lung: 2.2 nTPM
choroid plexus: 1.6 nTPM
cervix: 1.5 nTPM
hypothalamus: 1.1 nTPM

Single-cell type

late primary spermatocytes: 207 nCPM
epididymal efferent duct ciliated cells: 181 nCPM
early spermatids: 166 nCPM
respiratory ciliated cells: 157 nCPM
fallopian tube ciliated cells: 136 nCPM
endometrial ciliated cells: 89 nCPM

Immune cell

neutrophil: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
eosinophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM

Brain region

midbrain: 6.9 nTPM
medulla oblongata: 3.6 nTPM
spinal cord: 2 nTPM
choroid plexus: 1.4 nTPM
pons: 1.4 nTPM
hypothalamus: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cilia- and flagella-associated protein 141
Cilia- and flagella-associated protein 141

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP141 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NME7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP141 as an antibody target. Whether an autoantibody or antibody against CFAP141 could matter depends on whether native CFAP141 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP141 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP141 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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