Seroatlas · Human Serome Atlas

NECTIN3

Nectin-3

Also known as: CD113, CDw113, DKFZP566B0846, NECT3_HUMAN, nectin-3, PPR3, PVRL3, PVRR3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQS3
Gene
NECTIN3
Ensembl
ENSG00000177707
Chromosome
3
Canonical length
549 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cell Junctions,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>Q9NQS3|NECTIN3
     1  MARTLRPSPL CPGGGKAQLS SASLLGAGLL LQPPTPPPLL LLLFPLLLFS RLCGALAGPI
    61  IVEPHVTAVW GKNVSLKCLI EVNETITQIS WEKIHGKSSQ TVAVHHPQYG FSVQGEYQGR
   121  VLFKNYSLND ATITLHNIGF SDSGKYICKA VTFPLGNAQS STTVTVLVEP TVSLIKGPDS
   181  LIDGGNETVA AICIAATGKP VAHIDWEGDL GEMESTTTSF PNETATIISQ YKLFPTRFAR
   241  GRRITCVVKH PALEKDIRYS FILDIQYAPE VSVTGYDGNW FVGRKGVNLK CNADANPPPF
   301  KSVWSRLDGQ WPDGLLASDN TLHFVHPLTF NYSGVYICKV TNSLGQRSDQ KVIYISDPPT
   361  TTTLQPTIQW HPSTADIEDL ATEPKKLPFP LSTLATIKDD TIATIIASVV GGALFIVLVS
   421  VLAGIFCYRR RRTFRGDYFA KNYIPPSDMQ KESQIDVLQQ DELDSYPDSV KKENKNPVNN
   481  LIRKDYLEEP EKTQWNNVEN LNRFERPMDY YEDLKMGMKF VSDEHYDENE DDLVSHVDGS
   541  VISRREWYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NECTIN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • testis: 51 nTPM
  • thyroid gland: 40 nTPM
  • duodenum: 31 nTPM
  • liver: 27 nTPM
  • stomach: 23 nTPM
  • rectum: 22 nTPM

Single-cell type

  • late spermatids: 392 nCPM
  • syncytiotrophoblasts: 348 nCPM
  • sertoli cells: 317 nCPM
  • early spermatids: 315 nCPM
  • mucous neck cells: 267 nCPM
  • oligodendrocyte progenitor cells: 241 nCPM

Immune cell

  • memory CD4 T-cell: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • hypothalamus: 43 nTPM
  • medulla oblongata: 40 nTPM
  • white matter: 35 nTPM
  • spinal cord: 33 nTPM
  • cerebral cortex: 32 nTPM
  • hippocampal formation: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.92
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NECTIN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NECTIN3 as an antibody target. Whether an autoantibody or antibody against NECTIN3 could matter depends on whether native NECTIN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NECTIN3 is annotated at the cell surface, where native NECTIN3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NECTIN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NECTIN3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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