Seroatlas · Human Serome Atlas

PVRIG

Transmembrane protein PVRIG

Also known as: C7orf15, CD112R, MGC2463, PVRIG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6DKI7
Gene: PVRIG
Ensembl: ENSG00000213413
Chromosome: 7
Canonical length: 326 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Enables phosphatase binding activity and signaling receptor activity. Involved in negative regulation of T cell receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>Q6DKI7|PVRIG
     1  MRTEAQVPAL QPPEPGLEGA MGHRTLVLPW VLLTLCVTAG TPEVWVQVRM EATELSSFTI
    61  RCGFLGSGSI SLVTVSWGGP NGAGGTTLAV LHPERGIRQW APARQARWET QSSISLILEG
   121  SGASSPCANT TFCCKFASFP EGSWEACGSL PPSSDPGLSA PPTPAPILRA DLAGILGVSG
   181  VLLFGCVYLL HLLRRHKHRP APRLQPSRTS PQAPRARAWA PSQASQAALH VPYATINTSC
   241  RPATLDTAHP HGGPSWWASL PTHAAHRPQG PAAWASTPIP ARGSFVSVEN GLYAQAGERP
   301  PHTGPGLTLF PDPRGPRAME GPLGVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PVRIG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

thymus: 45 nTPM
spleen: 23 nTPM
lymph node: 21 nTPM
small intestine: 10 nTPM
appendix: 6.2 nTPM
tonsil: 5 nTPM

Single-cell type

nk-cells: 1.4 nCPM
t-cells: 1.2 nCPM
foveolar cells: 0.6 nCPM
b-cells: 0.5 nCPM
cardiomyocytes: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

MAIT T-cell: 353 nTPM
NK-cell: 335 nTPM
gdT-cell: 297 nTPM
memory CD8 T-cell: 294 nTPM
naive CD4 T-cell: 214 nTPM
naive CD8 T-cell: 212 nTPM

Brain region

white matter: 33 nTPM
medulla oblongata: 28 nTPM
cerebellum: 27 nTPM
basal ganglia: 25 nTPM
cerebral cortex: 25 nTPM
thalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of T cell receptor signaling pathway

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein PVRIG
Transmembrane protein PVRIG, immunoglobulin-like domain
Transmembrane protein PVRIG, immunoglobulin-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PVRIG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NECTIN2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PVRIG as an antibody target. Whether an autoantibody or antibody against PVRIG could matter depends on whether native PVRIG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PVRIG is annotated at the cell surface, where native PVRIG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PVRIG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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