Seroatlas · Human Serome Atlas

NCAPG

Condensin complex subunit 3

Also known as: CAP-G, CND3_HUMAN, FLJ12450, hCAP-G, YCG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BPX3
Gene: NCAPG
Ensembl: ENSG00000109805
Chromosome: 4
Canonical length: 1015 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

1015 residues, UniProt reviewed canonical sequence.

>Q9BPX3|NCAPG
     1  MGAERRLLSI KEAFRLAQQP HQNQAKLVVA LSRTYRTMDD KTVFHEEFIH YLKYVMVVYK
    61  REPAVERVIE FAAKFVTSFH QSDMEDDEEE EDGGLLNYLF TFLLKSHEAN SNAVRFRVCL
   121  LINKLLGSMP ENAQIDDDVF DKINKAMLIR LKDKIPNVRI QAVLALSRLQ DPKDDECPVV
   181  NAYATLIEND SNPEVRRAVL SCIAPSAKTL PKIVGRTKDV KEAVRKLAYQ VLAEKVHMRA
   241  MSIAQRVMLL QQGLNDRSDA VKQAMQKHLL QGWLRFSEGN ILELLHRLDV ENSSEVAVSV
   301  LNALFSITPL SELVGLCKNN DGRKLIPVET LTPEIALYWC ALCEYLKSKG DEGEEFLEQI
   361  LPEPVVYADY LLSYIQSIPV VNEEHRGDFS YIGNLMTKEF IGQQLILIIK SLDTSEEGGR
   421  KKLLAVLQEI LILPTIPISL VSFLVERLLH IIIDDNKRTQ IVTEIISEIR APIVTVGVNN
   481  DPADVRKKEL KMAEIKVKLI EAKEALENCI TLQDFNRASE LKEEIKALED ARINLLKETE
   541  QLEIKEVHIE KNDAETLQKC LILCYELLKQ MSISTGLSAT MNGIIESLIL PGIISIHPVV
   601  RNLAVLCLGC CGLQNQDFAR KHFVLLLQVL QIDDVTIKIS ALKAIFDQLM TFGIEPFKTK
   661  KIKTLHCEGT EINSDDEQES KEVEETATAK NVLKLLSDFL DSEVSELRTG AAEGLAKLMF
   721  SGLLVSSRIL SRLILLWYNP VTEEDVQLRH CLGVFFPVFA YASRTNQECF EEAFLPTLQT
   781  LANAPASSPL AEIDITNVAE LLVDLTRPSG LNPQAKTSQD YQALTVHDNL AMKICNEILT
   841  SPCSPEIRVY TKALSSLELS SHLAKDLLVL LNEILEQVKD RTCLRALEKI KIQLEKGNKE
   901  FGDQAEAAQD ATLTTTTFQN EDEKNKEVYM TPLRGVKATQ ASKSTQLKTN RGQRKVTVSA
   961  RTNRRCQTAE ADSESDHEVP EPESEMKMRL PRRAKTAALE KSKLNLAQFL NEDLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCAPG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

thymus: 15 nTPM
bone marrow: 13 nTPM
lymph node: 8.1 nTPM
tonsil: 8.1 nTPM
testis: 5.2 nTPM
appendix: 3.9 nTPM

Single-cell type

monocyte progenitors: 138 nCPM
erythrocyte progenitors: 138 nCPM
early primary spermatocytes: 80 nCPM
megakaryocyte progenitors: 65 nCPM
neutrophil progenitors: 64 nCPM
extravillous trophoblasts: 37 nCPM

Immune cell

T-reg: 0.6 nTPM
total PBMC: 0.4 nTPM
memory CD4 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

midbrain: 3 nTPM
spinal cord: 2.9 nTPM
pons: 1.9 nTPM
medulla oblongata: 1.5 nTPM
cerebellum: 1.4 nTPM
hypothalamus: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0
gnomAD missense Z: 1.1
DepMap mean gene effect: -1.66
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
Nuclear condensin complex subunit 3, C-terminal domain
Condensin complex subunit 3
Nuclear condensing complex subunits, C-term domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCAPG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCAPG as an antibody target. Whether an autoantibody or antibody against NCAPG could matter depends on whether native NCAPG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCAPG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCAPG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...