Seroatlas · Human Serome Atlas

CFAP70

Cilia- and flagella-associated protein 70

Also known as: CFA70_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T0N1
Gene: CFAP70
Canonical length: 1121 aa
Protein class: Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CFAP70 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1121 residues, UniProt reviewed canonical sequence.

>Q5T0N1|CFAP70
     1  MEQVPSAGRL VQITVTEGYD LKGFKGDTPV TFIRAEFNQV VLGDSAKITV SPEGSAKYNF
    61  TSSFEFNPEG GITSDDLAHK PVFLTVTEVL PKEKKQKEEK TLILGQAVVD LLPLLEGQSS
   121  FQTTVPLHPV QGSPLETPRS SAKQCSLEVK VLVAEPLLTT AQISGGNLLK VTLEAAYSVP
   181  ESFIPTGPGQ NYMVGLQVPS LGEKDYPILF KNGTLKLGGE REPVPRPKKW PIANILAPGA
   241  NNIPDAFIVG GPYEEEEGEL NHPEDSEFRN QAECIKKRII WDLESRCYLD PSAVVSFQKR
   301  IADCRLWPVE ITRVPLVTIP KGKAGKTEKT DEEAQLSFHG VAYVNMVPLL YPGVKRIRGA
   361  FHVYPYLDSV VHEKTKCLLS LFRDIGHHLI HNNKIGGINS LLSKQAVSKN LKEDKPVKEK
   421  DIDGRPRPGD VQAPSIKSQS SDTPLEGEPP LSHNPEGQQY VEAGTYIVLE IQLDKALVPK
   481  RMPEELARRV KEMIPPRPPL TRRTGGAQKA MSDYHIQIKN ISRAILDEYY RMFGKQVAKL
   541  ESDMDSETLE EQKCQLSYEL NCSGKYFAFK EQLKHAVVKI VRDKYLKTTS FESQEELQTF
   601  ISELYVFLVD QMHVALNQTM PDDVQGTVAT IYTSSEQLQL FAFEAEVNEN FEMAAAYYKE
   661  RLVREPQNLD HWLDYGAFCL LTEDNIKAQE CFQKALSLNQ SHIHSLLLCG VLAVLLENYE
   721  QAEIFFEDAT CLEPTNVVAW TLLGLYYEIQ NNDIRMEMAF HEASKQLQAR MLQAQVTKQK
   781  STGVEDTEER GKRESSLGPW GITNGSATAI KVEAPAGPGA ALSILDKFLE ESSKLQSDSQ
   841  EPILTTQTWD PSISQKPSNT FIKEIPTKKE ASKCQDSSAL LHPGLHYGVS QTTTIFMETI
   901  HFLMKVKAVQ YVHRVLAHEL LCPQGGPSCE YYLVLAQTHI LKKNFAKAEE YLQQAAQMDY
   961  LNPNVWGLKG HLYFLSGNHS EAKACYERTI SFVVDASEMH FIFLRLGLIY LEEKEYEKAK
  1021  KTYMQACKRS PSCLTWLGLG IACYRLEELT EAEDALSEAN ALNNYNAEVW AYLALVCLKV
  1081  GRQLEAEQAY KYMIKLKLKD EALLAEIHTL QETVGFGNPS F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP70 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 57 nTPM
testis: 19 nTPM
fallopian tube: 13 nTPM
pituitary gland: 13 nTPM
epididymis: 11 nTPM
retina: 9.6 nTPM

Single-cell type

ependymal cells: 1,126 nCPM
respiratory ciliated cells: 673 nCPM
choroid plexus epithelial cells: 485 nCPM
endometrial ciliated cells: 408 nCPM
fallopian tube ciliated cells: 360 nCPM
epididymal efferent duct ciliated cells: 248 nCPM

Immune cell

naive CD4 T-cell: 0.5 nTPM
naive CD8 T-cell: 0.4 nTPM
T-reg: 0.4 nTPM
naive B-cell: 0.3 nTPM
plasmacytoid DC: 0.2 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

choroid plexus: 42 nTPM
midbrain: 21 nTPM
medulla oblongata: 16 nTPM
spinal cord: 13 nTPM
pons: 9.7 nTPM
white matter: 8.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CFAP70.

Disease | AllUniProt

Conditions CFAP70 is implicated in, by any mechanism.

Spermatogenic failure 41 (SPGF41) MIM:618670

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 93 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 41

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Tetratricopeptide repeat
Cilia- and flagella-associated protein 70

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP70 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP70 as an antibody target. Whether an autoantibody or antibody against CFAP70 could matter depends on whether native CFAP70 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP70 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP70 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...