MUC2

Protein identityUniProt · HPA

UniProt accession

Q02817

Gene

MUC2

Canonical length

5289 aa

Protein class

Predicted intracellular proteins

Quaternary structure

Homomultimer

OverviewNCBI Gene

No narrative summary is available for MUC2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

5289 residues, UniProt reviewed canonical sequence.

>Q02817|MUC2
     1  MGLPLARLAA VCLALSLAGG SELQTEGRTR NHGHNVCSTW GNFHYKTFDG DVFRFPGLCD
    61  YNFASDCRGS YKEFAVHLKR GPGQAEAPAG VESILLTIKD DTIYLTRHLA VLNGAVVSTP
   121  HYSPGLLIEK SDAYTKVYSR AGLTLMWNRE DALMLELDTK FRNHTCGLCG DYNGLQSYSE
   181  FLSDGVLFSP LEFGNMQKIN QPDVVCEDPE EEVAPASCSE HRAECERLLT AEAFADCQDL
   241  VPLEPYLRAC QQDRCRCPGG DTCVCSTVAE FSRQCSHAGG RPGNWRTATL CPKTCPGNLV
   301  YLESGSPCMD TCSHLEVSSL CEEHRMDGCF CPEGTVYDDI GDSGCVPVSQ CHCRLHGHLY
   361  TPGQEITNDC EQCVCNAGRW VCKDLPCPGT CALEGGSHIT TFDGKTYTFH GDCYYVLAKG
   421  DHNDSYALLG ELAPCGSTDK QTCLKTVVLL ADKKKNVVVF KSDGSVLLNE LQVNLPHVTA
   481  SFSVFRPSSY HIMVSMAIGV RLQVQLAPVM QLFVTLDQAS QGQVQGLCGN FNGLEGDDFK
   541  TASGLVEATG AGFANTWKAQ SSCHDKLDWL DDPCSLNIES ANYAEHWCSL LKKTETPFGR
   601  CHSAVDPAEY YKRCKYDTCN CQNNEDCLCA ALSSYARACT AKGVMLWGWR EHVCNKDVGS
   661  CPNSQVFLYN LTTCQQTCRS LSEADSHCLE GFAPVDGCGC PDHTFLDEKG RCVPLAKCSC
   721  YHRGLYLEAG DVVVRQEERC VCRDGRLHCR QIRLIGQSCT APKIHMDCSN LTALATSKPR
   781  ALSCQTLAAG YYHTECVSGC VCPDGLMDDG RGGCVVEKEC PCVHNNDLYS SGAKIKVDCN
   841  TCTCKRGRWV CTQAVCHGTC SIYGSGHYIT FDGKYYDFDG HCSYVAVQDY CGQNSSLGSF
   901  SIITENVPCG TTGVTCSKAI KIFMGRTELK LEDKHRVVIQ RDEGHHVAYT TREVGQYLVV
   961  ESSTGIIVIW DKRTTVFIKL APSYKGTVCG LCGNFDHRSN NDFTTRDHMV VSSELDFGNS
  1021  WKEAPTCPDV STNPEPCSLN PHRRSWAEKQ CSILKSSVFS ICHSKVDPKP FYEACVHDSC
  1081  SCDTGGDCEC FCSAVASYAQ ECTKEGACVF WRTPDLCPIF CDYYNPPHEC EWHYEPCGNR
  1141  SFETCRTING IHSNISVSYL EGCYPRCPKD RPIYEEDLKK CVTADKCGCY VEDTHYPPGA
  1201  SVPTEETCKS CVCTNSSQVV CRPEEGKILN QTQDGAFCYW EICGPNGTVE KHFNICSITT
  1261  RPSTLTTFTT ITLPTTPTTF TTTTTTTTPT SSTVLSTTPK LCCLWSDWIN EDHPSSGSDD
  1321  GDRETFDGVC GAPEDIECRS VKDPHLSLEQ LGQKVQCDVS VGFICKNEDQ FGNGPFGLCY
  1381  DYKIRVNCCW PMDKCITTPS PPTTTPSPPP TSTTTLPPTT TPSPPTTTTT TPPPTTTPSP
  1441  PITTTTTPPP TTTPSPPIST TTTPPPTTTP SPPTTTPSPP TTTPSPPTTT TTTPPPTTTP
  1501  SPPTTTPITP PASTTTLPPT TTPSPPTTTT TTPPPTTTPS PPTTTPITPP TSTTTLPPTT
  1561  TPSPPPTTTT TPPPTTTPSP PTTTTPSPPT ITTTTPPPTT TPSPPTTTTT TPPPTTTPSP
  1621  PTTTPITPPT STTTLPPTTT PSPPPTTTTT PPPTTTPSPP TTTTPSPPIT TTTTPPPTTT
  1681  PSSPITTTPS PPTTTMTTPS PTTTPSSPIT TTTTPSSTTT PSPPPTTMTT PSPTTTPSPP
  1741  TTTMTTLPPT TTSSPLTTTP LPPSITPPTF SPFSTTTPTT PCVPLCNWTG WLDSGKPNFH
  1801  KPGGDTELIG DVCGPGWAAN ISCRATMYPD VPIGQLGQTV VCDVSVGLIC KNEDQKPGGV
  1861  IPMAFCLNYE INVQCCECVT QPTTMTTTTT ENPTPTPITT TTTVTPTPTP TSTQSTTPTP
  1921  ITTTNTVTPT PTPTGTQTPT PTPITTTTTM VTPTPTITST QTPTPTPITT TTVTPTPTPT
  1981  STQRTTPTSI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPISTTT
  2041  MVTPTPTPTG TQTLTPTPIT TTTTVTPTPT PTGTQTPTST PISTTTTVTP TPTPTGTQTP
  2101  TLTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTKSTTPTS ITTTTMVTPT
  2161  PPPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTPTPITTT TTVTPTPTPT GTQTPTSTPI
  2221  TTNTTVTPTP TPTGTPSTTL TPITTTTMVT PTPTPTGTQT PTSTPISTTT TVTPTPTPTG
  2281  TQTPTPTPIS TTTTVTPTPT PTSTQTPTTT PITTTTTVTP NPTPTGTQTP TTTPITTTTT
  2341  VTPTPTPTGT QTPTTTPIST TTTVTPTPTP TGTQTPTTTA ITTTTTVTPT PTPTGTQTPT
  2401  STPITTTTTV TPTPTPTGTQ TPTSTPISNT TTVTPTPTPT GTQTPTVTPI TTTTTVTPTR
  2461  TPTGTKSTTP TSITTTTMVT PTPTPTGTHT PTTTPITTTT TVTPTPTPTG TQTPTPTPIT
  2521  TTTTVTPTPT PTGTQTPTST PITTTTTVTP TPTPTGTQTP TTTPITTNTT VTPTPTPTGT
  2581  QTPTTVLITT TTTMTPTPTP TSTKSTTVTP ITTTTTVTPT PTPTGTQSTT LTPITTTTTV
  2641  TPTPTPTGTQ TPTTTPISTT TTVIPTPTPT GTQTPTSTPI TTTTTVTPTP TPTGTQTPTS
  2701  TPISTTTTVT PTATPTGTQT PTLTPITTTT TVTSTPTPTG TQTPTPTPIT TTTTVTPTPT
  2761  PTSTQTPTST PITTTTTVTP TPTPTGTQTP TTTHITTTTT VTPTPTPTGT QAPTPTAITT
  2821  TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQSPT PTAITTTTTV TPTPTPTGTQ
  2881  TPTTTPITTT TTVTPTPTPT GTQSTTLTPI TTTTTVTPIP TPTGTQTPTS TPITTTITVT
  2941  PTPTPTGTQT PTPTPISTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT
  3001  PISTTTTVTP TPTPTGTQTP TSTPITTTTT VTPTPTPTGT QTPTPTPITT TTTVTPTPTP
  3061  TGTQTPTSTP ITTTTTVTPT PTPTGTQTPT PTPITTTTTV TPTPTPTGTQ TPTSTPITTT
  3121  TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQSTTL TPITTTTTVT PTPTPTGTQT
  3181  PTSTPITTTT TVTPTPTGTQ TPTPTPISTT TTVTPTPTPT GTQTPTMTPI TTTTTVTPTP
  3241  TPTGTQTPTT TPISTTTTVT PTPTPTGTQT PTSTPITTTT TVTPTPTPTG TQTPTTTPIT
  3301  TTTTVTPTPT PTGTQSTTLT PITTTTTVTP TPTPTGTQTP TPTPISTTTT VTPTPTPTGT
  3361  QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ISTTTTVTPT PTPTGTQTPT STPITTTTTV
  3421  TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQAPTPTAI TTTTTVTPTP TPTGTQTPTT
  3481  TPITTTTMVT PTPTPTGTQT PTSTPITTTT TVTPTPTPTG TQTPTPTPIS TTTTVTPTPT
  3541  PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPISTTTT VTPTPTPTGT QTPTSTPITT
  3601  TTTVTPTPTP TGTQTPTPTP ITTTTTVTPT PTPTGTQTPT STPITTTTTV TPTPTPTGTQ
  3661  TPTTTPITTT TTVTPTPTPT GTQSTTLTPI TTTTTVTPTP TPTGTQTPTS TPITTTTTVT
  3721  PTPTPTGTQT PTPTPISTTS TVTPTPTPTG TQTPTMTPIT TTTTVTPTPT PTGTQTPTST
  3781  PITTTTTVTP TPTPTGTQTP TMTPITTTTT VTPTPTPTGT QAPTPTAITT TTTVTPTPTP
  3841  TGTQTPTTTP ITTTTTVTPT PTPTGTQSTT LTPITTTTTV TPTPTPTGTQ TPTPTPISTT
  3901  TTVTPTPTPT GTQTPTMTPI TTTTTVTPTP TPTGTQTPTT TPISTTTTVT PTPTPTGTQT
  3961  PTTTPITTTT TVTPTPTPTG TQTPTTTPIS TTTTVTPTPT PTGTQTPTTT PITTTTTVTP
  4021  TPTPTGTQTP TTTPISTTTT VTPTPTPTGT QTPTSTPITT TTTVTPTPTP TGTQTPTTTP
  4081  ITTTTTVTPT PTPTGTQAPT PTAITTTSTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT
  4141  GTQSPTPTAI TTTTTVTPTP TPTGTQTPTL TPITTTTTVT PTPTPTGTQT PTPTPISTTT
  4201  TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTV LITTTTTMTP TPTPTSTKST
  4261  TVTPITTTTT VTATPTPTGT QTPTMIPIST TTTVTPTPTP TTGSTGPPTH TSTAPIAELT
  4321  TSNPPPESST PQTSRSTSSP LTESTTLLST LPPAIEMTST APPSTPTAPT TTSGGHTLSP
  4381  PPSTTTSPPG TPTRGTTTGS SSAPTPSTVQ TTTTSAWTPT PTPLSTPSII RTTGLRPYPS
  4441  SVLICCVLND TYYAPGEEVY NGTYGDTCYF VNCSLSCTLE FYNWSCPSTP SPTPTPSKST
  4501  PTPSKPSSTP SKPTPGTKPP ECPDFDPPRQ ENETWWLCDC FMATCKYNNT VEIVKVECEP
  4561  PPMPTCSNGL QPVRVEDPDG CCWHWECDCY CTGWGDPHYV TFDGLYYSYQ GNCTYVLVEE
  4621  ISPSVDNFGV YIDNYHCDPN DKVSCPRTLI VRHETQEVLI KTVHMMPMQV QVQVNRQAVA
  4681  LPYKKYGLEV YQSGINYVVD IPELGVLVSY NGLSFSVRLP YHRFGNNTKG QCGTCTNTTS
  4741  DDCILPSGEI VSNCEAAADQ WLVNDPSKPH CPHSSSTTKR PAVTVPGGGK TTPHKDCTPS
  4801  PLCQLIKDSL FAQCHALVPP QHYYDACVFD SCFMPGSSLE CASLQAYAAL CAQQNICLDW
  4861  RNHTHGACLV ECPSHREYQA CGPAEEPTCK SSSSQQNNTV LVEGCFCPEG TMNYAPGFDV
  4921  CVKTCGCVGP DNVPREFGEH FEFDCKNCVC LEGGSGIICQ PKRCSQKPVT HCVEDGTYLA
  4981  TEVNPADTCC NITVCKCNTS LCKEKPSVCP LGFEVKSKMV PGRCCPFYWC ESKGVCVHGN
  5041  AEYQPGSPVY SSKCQDCVCT DKVDNNTLLN VIACTHVPCN TSCSPGFELM EAPGECCKKC
  5101  EQTHCIIKRP DNQHVILKPG DFKSDPKNNC TFFSCVKIHN QLISSVSNIT CPNFDASICI
  5161  PGSITFMPNG CCKTCTPRNE TRVPCSTVPV TTEVSYAGCT KTVLMNHCSG SCGTFVMYSA
  5221  KAQALDHSCS CCKEEKTSQR EVVLSCPNGG SLTHTYTHIE SCQCQDTVCG LPTGTSRRAR
  5281  RSPRHLGSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0

Highest tissue expression

437 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MUC2.

Disease | ImmuneIEDB

Conditions an epitope on MUC2 was assayed in.

• colorectal cancer T cell

ReferencesPubMed · IEDB

Publications for MUC2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.43

gnomAD pLI

0

gnomAD missense Z

1.31

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• detoxification of copper ion
• host-mediated modulation of intestinal microbiota composition
• maintenance of gastrointestinal epithelium
• mucus secretion

Molecular functions

• cupric ion binding
• cuprous ion binding

Cellular components

• extracellular matrix
• Golgi lumen
• plasma membrane
• inner mucus layer
• outer mucus layer

Protein domainsUniProt · Pfam · InterPro

• VWFC domain
• von Willebrand factor, type D domain
• Trypsin Inhibitor-like, cysteine rich domain
• Cystine knot, C-terminal
• VWF/SSPO/Zonadhesin-like, cysteine-rich domain
• WxxW domain
• Serine protease inhibitor-like superfamily
• Mucin/von Willebrand/Thrombospondin superfamily
• Otogelin-like/Mucin, TIL domain
• von Willebrand factor type D domain
• Trypsin Inhibitor like cysteine rich domain
• C8 domain
• Mucin-2 protein WxxW repeating region
• Von Willebrand factor-like domain
• Otogelin-like/Mucin TIL domain

KeywordsUniProt

• Autocatalytic cleavage
• Calcium
• Copper
• Disulfide bond
• Glycoprotein
• Phosphoprotein
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of MUC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AGR2
• FCGBP