Seroatlas · Human Serome Atlas

FCGBP

IgGFc-binding protein

Also known as: FCGBP_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6R7
Gene
FCGBP
Canonical length
5405 aa
Protein class
Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for FCGBP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

5405 residues, UniProt reviewed canonical sequence.

>Q9Y6R7|FCGBP
     1  MGALWSWWIL WAGATLLWGL TQEASVDLKN TGREEFLTAF LQNYQLAYSK AYPRLLISSL
    61  SESPASVSIL SQADNTSKKV TVRPGESVMV NISAKAEMIG SKIFQHAVVI HSDYAISVQA
   121  LNAKPDTAEL TLLRPIQALG TEYFVLTPPG TSARNVKEFA VVAGAAGASV SVTLKGSVTF
   181  NGKFYPAGDV LRVTLQPYNV AQLQSSVDLS GSKVTASSPV AVLSGHSCAQ KHTTCNHVVE
   241  QLLPTSAWGT HYVVPTLASQ SRYDLAFVVA SQATKLTYNH GGITGSRGLQ AGDVVEFEVR
   301  PSWPLYLSAN VGIQVLLFGT GAIRNEVTYD PYLVLIPDVA AYCPAYVVKS VPGCEGVALV
   361  VAQTKAISGL TIDGHAVGAK LTWEAVPGSE FSYAEVELGT ADMIHTAEAT TNLGLLTFGL
   421  AKAIGYATAA DCGRTVLSPV EPSCEGMQCA AGQRCQVVGG KAGCVAESTA VCRAQGDPHY
   481  TTFDGRRYDM MGTCSYTMVE LCSEDDTLPA FSVEAKNEHR GSRRVSYVGL VTVRAYSHSV
   541  SLTRGEVGFV LVDNQRSRLP VSLSEGRLRV YQSGPRAVVE LVFGLVVTYD WDCQLALSLP
   601  ARFQDQVCGL CGNYNGDPAD DFLTPDGALA PDAVEFASSW KLDDGDYLCE DGCQNNCPAC
   661  TPGQAQHYEG DRLCGMLTKL DGPFAVCHDT LDPRPFLEQC VYDLCVVGGE RLSLCRGLSA
   721  YAQACLELGI SVGDWRSPAN CPLSCPANSR YELCGPACPT SCNGAAAPSN CSGRPCVEGC
   781  VCLPGFVASG GACVPASSCG CTFQGLQLAP GQEVWADELC QRRCTCNGAT HQVTCRDKQS
   841  CPAGERCSVQ NGLLGCYPDR FGTCQGSGDP HYVSFDGRRF DFMGTCTYLL VGSCGQNAAL
   901  PAFRVLVENE HRGSQTVSYT RAVRVEARGV KVAVRREYPG QVLVDDVLQY LPFQAADGQV
   961  QVFRQGRDAV VRTDFGLTVT YDWNARVTAK VPSSYAEALC GLCGNFNGDP ADDLALRGGG
  1021  QAANALAFGN SWQEETRPGC GATEPGDCPK LDSLVAQQLQ SKNECGILAD PKGPFRECHS
  1081  KLDPQGAVRD CVYDRCLLPG QSGPLCDALA TYAAACQAAG ATVHPWRSEE LCPLSCPPHS
  1141  HYEACSYGCP LSCGDLPVPG GCGSECHEGC VCDEGFALSG ESCLPLASCG CVHQGTYHPP
  1201  GQTFYPGPGC DSLCHCQEGG LVSCESSSCG PHEACQPSGG SLGCVAVGSS TCQASGDPHY
  1261  TTFDGRRFDF MGTCVYVLAQ TCGTRPGLHR FAVLQENVAW GNGRVSVTRV ITVQVANFTL
  1321  RLEQRQWKVT VNGVDMKLPV VLANGQIRAS QHGSDVVIET DFGLRVAYDL VYYVRVTVPG
  1381  NYYQQMCGLC GNYNGDPKDD FQKPNGSQAG NANEFGNSWE EVVPDSPCLP PTPCPPGSED
  1441  CIPSHKCPPE LEKKYQKEEF CGLLSSPTGP LSSCHKLVDP QGPLKDCIFD LCLGGGNLSI
  1501  LCSNIHAYVS ACQAAGGHVE PWRTETFCPM ECPPNSHYEL CADTCSLGCS ALSAPPQCQD
  1561  GCAEGCQCDS GFLYNGQACV PIQQCGCYHN GVYYEPEQTV LIDNCRQQCT CHAGKGMVCQ
  1621  EHSCKPGQVC QPSGGILSCV TKDPCHGVTC RPQETCKEQG GQGVCLPNYE ATCWLWGDPH
  1681  YHSFDGRKFD FQGTCNYVLA TTGCPGVSTQ GLTPFTVTTK NQNRGNPAVS YVRVVTVAAL
  1741  GTNISIHKDE IGKVRVNGVL TALPVSVADG RISVTQGASK ALLVADFGLQ VSYDWNWRVD
  1801  VTLPSSYHGA VCGLCGNMDR NPNNDQVFPN GTLAPSIPIW GGSWRAPGWD PLCWDECRGS
  1861  CPTCPEDRLE QYEGPGFCGP LAPGTGGPFT TCHAHVPPES FFKGCVLDVC MGGGDRDILC
  1921  KALASYVAAC QAAGVVIEDW RAQVGCEITC PENSHYEVCG SPCPASCPSP APLTTPAVCE
  1981  GPCVEGCQCD AGFVLSADRC VPLNNGCGCW ANGTYHEAGS EFWADGTCSQ WCRCGPGGGS
  2041  LVCTPASCGL GEVCGLLPSG QHGCQPVSTA ECQAWGDPHY VTLDGHRFNF QGTCEYLLSA
  2101  PCHGPPLGAE NFTVTVANEH RGSQAVSYTR SVTLQIYNHS LTLSARWPRK LQVDGVFVTL
  2161  PFQLDSLLHA HLSGADVVVT TTSGLSLAFD GDSFVRLRVP AAYAGSLCGL CGNYNQDPAD
  2221  DLKAVGGKPA GWQVGGAQGC GECVSKPCPS PCTPEQQESF GGPDACGVIS ATDGPLAPCH
  2281  GLVPPAQYFQ GCLLDACQVQ GHPGGLCPAV ATYVAACQAA GAQLREWRRP DFCPFQCPAH
  2341  SHYELCGDSC PGSCPSLSAP EGCESACREG CVCDAGFVLS GDTCVPVGQC GCLHDDRYYP
  2401  LGQTFYPGPG CDSLCRCREG GEVSCEPSSC GPHETCRPSG GSLGCVAVGS TTCQASGDPH
  2461  YTTFDGRRFD FMGTCVYVLA QTCGTRPGLH RFAVLQENVA WGNGRVSVTR VITVQVANFT
  2521  LRLEQRQWKV TVNGVDMKLP VVLANGQIRA SQHGSDVVIE TDFGLRVAYD LVYYVRVTVP
  2581  GNYYQLMCGL CGNYNGDPKD DFQKPNGSQA GNANEFGNSW EEVVPDSPCL PPPTCPPGSE
  2641  GCIPSEECPP ELEKKYQKEE FCGLLSSPTG PLSSCHKLVD PQGPLKDCIF DLCLGGGNLS
  2701  ILCSNIHAYV SACQAAGGQV EPWRNETFCP MECPQNSHYE LCADTCSLGC SALSAPLQCP
  2761  DGCAEGCQCD SGFLYNGQAC VPIQQCGCYH NGAYYEPEQT VLIDNCRQQC TCHVGKVVVC
  2821  QEHSCKPGQV CQPSGGILSC VNKDPCHGVT CRPQETCKEQ GGQGVCLPNY EATCWLWGDP
  2881  HYHSFDGRKF DFQGTCNYVL ATTGCPGVST QGLTPFTVTT KNQNRGNPAV SYVRVVTVAA
  2941  LGTNISIHKD EIGKVRVNGV LTALPVSVAD GRISVTQGAS KALLVADFGL QVSYDWNWRV
  3001  DVTLPSSYHG AVCGLCGNMD RNPNNDQVFP NGTLAPSIPI WGGSWRAPGW DPLCWDECRG
  3061  SCPTCPEDRL EQYEGPGFCG PLAPGTGGPF TTCHAHVPPE SFFKGCVLDV CMGGGDRDIL
  3121  CKALASYVAA CQAAGVVIED WRAQVGCEIT CPENSHYEVC GPPCPASCPS PAPLTTPAVC
  3181  EGPCVEGCQC DAGFVLSADR CVPLNNGCGC WANGTYHEAG SEFWADGTCS QWCRCGPGGG
  3241  SLVCTPASCG LGEVCGLLPS GQHGCQPVST AECQAWGDPH YVTLDGHRFD FQGTCEYLLS
  3301  APCHGPPLGA ENFTVTVANE HRGSQAVSYT RSVTLQIYNH SLTLSARWPR KLQVDGVFVT
  3361  LPFQLDSLLH AHLSGADVVV TTTSGLSLAF DGDSFVRLRV PAAYAGSLCG LCGNYNQDPA
  3421  DDLKAVGGKP AGWQVGGAQG CGECVSKPCP SPCTPEQQES FGGPDACGVI SATDGPLAPC
  3481  HGLVPPAQYF QGCLLDACQV QGHPGGLCPA VATYVAACQA AGAQLREWRR PDFCPFQCPA
  3541  HSHYELCGDS CPGSCPSLSA PEGCESACRE GCVCDAGFVL SGDTCVPVGQ CGCLHDDRYY
  3601  PLGQTFYPGP GCDSLCRCRE GGEVSCEPSS CGPHETCRPS GGSLGCVAVG STTCQASGDP
  3661  HYTTFDGHRF DFMGTCVYVL AQTCGTRPGL HRFAVLQENV AWGNGRVSVT RVITVQVANF
  3721  TLRLEQRQWK VTVNGVDMKL PVVLANGQIR ASQHGSDVVI ETDFGLRVAY DLVYYVRVTV
  3781  PGNYYQLMCG LCGNYNGDPK DDFQKPNGSQ AGNANEFGNS WEEVVPDSPC LPPPTCPPGS
  3841  AGCIPSDKCP PELEKKYQKE EFCGLLSSPT GPLSSCHKLV DPQGPLKDCI FDLCLGGGNL
  3901  SILCSNIHAY VSACQAAGGH VEPWRNETFC PMECPQNSHY ELCADTCSLG CSALSAPLQC
  3961  PDGCAEGCQC DSGFLYNGQA CVPIQQCGCY HNGVYYEPEQ TVLIDNCRQQ CTCHVGKVVV
  4021  CQEHSCKPGQ VCQPSGGILS CVTKDPCHGV TCRPQETCKE QGGQGVCLPN YEATCWLWGD
  4081  PHYHSFDGRK FDFQGTCNYV LATTGCPGVS TQGLTPFTVT TKNQNRGNPA VSYVRVVTVA
  4141  ALGTNISIHK DEIGKVRVNG VLTALPVSVA DGRISVAQGA SKALLVADFG LQVSYDWNWR
  4201  VDVTLPSSYH GAVCGLCGNM DRNPNNDQVF PNGTLAPSIP IWGGSWRAPG WDPLCWDECR
  4261  GSCPTCPEDR LEQYEGPGFC GPLSSGTGGP FTTCHAHVPP ESFFKGCVLD VCMGGGDRDI
  4321  LCKALASYVA ACQAAGVVIE DWRAQVGCEI TCPENSHYEV CGPPCPASCP SPAPLTTPAV
  4381  CEGPCVEGCQ CDAGFVLSAD RCVPLNNGCG CWANGTYHEA GSEFWADGTC SQWCRCGPGG
  4441  GSLVCTPASC GLGEVCGLLP SGQHGCQPVS TAECQAWGDP HYVTLDGHRF DFQGTCEYLL
  4501  SAPCHGPPLG AENFTVTVAN EHRGSQAVSY TRSVTLQIYN HSLTLSARWP RKLQVDGVFV
  4561  ALPFQLDSLL HAHLSGADVV VTTTSGLSLA FDGDSFVRLR VPAAYAASLC GLCGNYNQDP
  4621  ADDLKAVGGK PAGWQVGGAQ GCGECVSKPC PSPCTPEQQE SFGGPDACGV ISATDGPLAP
  4681  CHGLVPPAQY FQGCLLDACQ VQGHPGGLCP AVATYVAACQ AAGAQLGEWR RPDFCPLQCP
  4741  AHSHYELCGD SCPVSCPSLS APEGCESACR EGCVCDAGFV LSGDTCVPVG QCGCLHDGRY
  4801  YPLGEVFYPG PECERRCECG PGGHVTCQEG AACGPHEECR LEDGVQACHA TGCGRCLANG
  4861  GIHYITLDGR VYDLHGSCSY VLAQVCHPKP GDEDFSIVLE KNAAGDLQRL LVTVAGQVVS
  4921  LAQGQQVTVD GEAVALPVAV GRVRVTAEGR NMVLQTTKGL RLLFDGDAHL LMSIPSPFRG
  4981  RLCGLCGNFN GNWSDDFVLP NGSAASSVET FGAAWRAPGS SKGCGEGCGP QGCPVCLAEE
  5041  TAPYESNEAC GQLRNPQGPF ATCQAVLSPS EYFRQCVYDL CAQKGDKAFL CRSLAAYTAA
  5101  CQAAGVAVKP WRTDSFCPLH CPAHSHYSIC TRTCQGSCAA LSGLTGCTTR CFEGCECDDR
  5161  FLLSQGVCIP VQDCGCTHNG RYLPVNSSLL TSDCSERCSC SSSSGLTCQA AGCPPGRVCE
  5221  VKAEARNCWA TRGLCVLSVG ANLTTFDGAR GATTSPGVYE LSSRCPGLQN TIPWYRVVAE
  5281  VQICHGKTEA VGQVHIFFQD GMVTLTPNKG VWVNGLRVDL PAEKLASVSV SRTPDGSLLV
  5341  RQKAGVQVWL GANGKVAVIV SNDHAGKLCG ACGNFDGDQT NDWHDSQEKP AMEKWRAQDF
  5401  SPCYG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FCGBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0
Highest tissue expression
193 nTPM

Expression across tissuesHPA

Tissue

  • colon: 193 nTPM
  • small intestine: 145 nTPM
  • thyroid gland: 94 nTPM
  • salivary gland: 88 nTPM
  • stomach: 65 nTPM
  • rectum: 64 nTPM

Single-cell type

  • goblet cells: 10,323 nCPM
  • foveolar cells: 953 nCPM
  • prostatic club cells: 422 nCPM
  • colonocytes: 268 nCPM
  • endometrial secretory cells: 187 nCPM
  • loop of henle epithelial cells: 90 nCPM

Immune cell

  • naive CD8 T-cell: 0.5 nTPM
  • myeloid DC: 0.4 nTPM
  • gdT-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • intermediate monocyte: 0.1 nTPM

Brain region

  • medulla oblongata: 25 nTPM
  • thalamus: 17 nTPM
  • choroid plexus: 17 nTPM
  • white matter: 14 nTPM
  • pons: 13 nTPM
  • cerebral cortex: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
1.54

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FCGBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FCGBP as an antibody target. Whether an autoantibody or antibody against FCGBP could matter depends on whether native FCGBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FCGBP is annotated as secreted, so native FCGBP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FCGBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FCGBP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...