Otogelin-like/Mucin TIL domain

Definition

This entry describes a trypsin inhibitor-like (TIL) cysteine rich domain found in Otogelin, Otogelin-like proteins and Mucin proteins from eukaryotes. Otogelin is a structurally complex glycoprotein with specialised roles in the inner ear membranes. While it shares some structural similarities with mucins, including von Willebrand factor-like domains and cysteine-rich regions, it differs in its glycosylation patterns and functions. Otogelin undergoes primarily N-glycosylation and plays a critical role in the organisation of the extracellular matrix within the inner ear. In contrast, mucins like MUC5B and MUC19 are heavily O-glycosylated, gel-forming proteins that provide lubrication and protective barriers on mucosal epithelial surfaces [[cite:PMID:9405633],[cite:PMID:31776257],[cite:PMID:17911254],[cite:PMID:40004452],[cite:PMID:17950376]]. The TIL domain is characterised by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues PMID:11353828.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• MUC19
• MUC2
• MUC5AC
• MUC5B
• OTOG
• OTOGL
• VWF