Seroatlas · Human Serome Atlas

MTCL2

Microtubule cross-linking factor 2

Also known as: C20orf117, dJ132F21.1, FLJ44670, KIAA0889, MTCL2_HUMAN, SOGA, SOGA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94964
Gene: MTCL2
Ensembl: ENSG00000149639
Chromosome: 20
Canonical length: 1661 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoli,Cytosol
Secretome location: Secreted to blood

OverviewNCBI Gene

Involved in chromosome segregation. Located in extracellular space; microtubule; and midbody. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1661 residues, UniProt reviewed canonical sequence.

>O94964|MTCL2
     1  MEAPAAEPPV RGCGPQPAPA PAPAPERKKS HRAPSPARPK DVAGWSLAKG RRGPGPGSAV
    61  ACSAAFSSRP DKKGRAVAPG ARGAGVRVAG VRTGVRAKGR PRSGAGPRPP PPPPSLTDSS
   121  SEVSDCASEE ARLLGLELAL SSDAESAAGG PAGVRTGQPA QPAPSAQQPP RPPASPDEPS
   181  VAASSVGSSR LPLSASLAFS DLTEEMLDCG PSGLVRELEE LRSENDYLKD EIEELRAEML
   241  EMRDVYMEED VYQLQELRQQ LDQASKTCRI LQYRLRKAER RSLRAAQTGQ VDGELIRGLE
   301  QDVKVSKDIS MRLHKELEVV EKKRARLEEE NEELRQRLIE TELAKQVLQT ELERPREHSL
   361  KKRGTRSLGK ADKKTLVQED SADLKCQLHF AKEESALMCK KLTKLAKEND SMKEELLKYR
   421  SLYGDLDSAL SAEELADAPH SRETELKVHL KLVEEEANLL SRRIVELEVE NRGLRAEMDD
   481  MKDHGGGCGG PEARLAFSAL GGGECGESLA ELRRHLQFVE EEAELLRRSS AELEDQNKLL
   541  LNELAKFRSE HELDVALSED SCSVLSEPSQ EELAAAKLQI GELSGKVKKL QYENRVLLSN
   601  LQRCDLASCQ STRPMLETDA EAGDSAQCVP APLGETHESH AVRLCRAREA EVLPGLREQA
   661  ALVSKAIDVL VADANGFTAG LRLCLDNECA DFRLHEAPDN SEGPRDTKLI HAILVRLSVL
   721  QQELNAFTRK ADAVLGCSVK EQQESFSSLP PLGSQGLSKE ILLAKDLGSD FQPPDFRDLP
   781  EWEPRIREAF RTGDLDSKPD PSRSFRPYRA EDNDSYASEI KELQLVLAEA HDSLRGLQEQ
   841  LSQERQLRKE EADNFNQKMV QLKEDQQRAL LRREFELQSL SLQRRLEQKF WSQEKNMLVQ
   901  ESQQFKHNFL LLFMKLRWFL KRWRQGKVLP SEGDDFLEVN SMKELYLLME EEEINAQHSD
   961  NKACTGDSWT QNTPNEYIKT LADMKVTLKE LCWLLRDERR GLTELQQQFA KAKATWETER
  1021  AELKGHTSQM ELKTGKGAGE RAGPDWKAAL QREREEQQHL LAESYSAVME LTRQLQISER
  1081  NWSQEKLQLV ERLQGEKQQV EQQVKELQNR LSQLQKAADP WVLKHSELEK QDNSWKETRS
  1141  EKIHDKEAVS EVELGGNGLK RTKSVSSMSE FESLLDCSPY LAGGDARGKK LPNNPAFGFV
  1201  SSEPGDPEKD TKEKPGLSSR DCNHLGALAC QDPPGRQMQR SYTAPDKTGI RVYYSPPVAR
  1261  RLGVPVVHDK EGKIIIEPGF LFTTAKPKES AEADGLAESS YGRWLCNFSR QRLDGGSAGS
  1321  PSAAGPGFPA ALHDFEMSGN MSDDMKEITN CVRQAMRSGS LERKVKSTSS QTVGLASVGT
  1381  QTIRTVSVGL QTDPPRSSLH GKAWSPRSSS LVSVRSKQIS SSLDKVHSRI ERPCCSPKYG
  1441  SPKLQRRSVS KLDSSKDRSL WNLHQGKQNG SAWARSTTTR DSPVLRNIND GLSSLFSVVE
  1501  HSGSTESVWK LGMSETRAKP EPPKYGIVQE FFRNVCGRAP SPTSSAGEEG TKKPEPLSPA
  1561  SYHQPEGVAR ILNKKAAKLG SSEEVRLTML PQVGKDGVLR DGDGAVVLPN EDAVCDCSTQ
  1621  SLTSCFARSS RSAIRHSPSK CRLHPSESSW GGEERALPPS E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTCL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 71 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 71 nTPM
adrenal gland: 14 nTPM
colon: 12 nTPM
thyroid gland: 11 nTPM
endometrium: 11 nTPM
urinary bladder: 11 nTPM

Single-cell type

sertoli cells: 184 nCPM
oligodendrocytes: 144 nCPM
adrenal cortex cells: 128 nCPM
brain excitatory neurons: 110 nCPM
retinal ganglion cells: 108 nCPM
loop of henle epithelial cells: 106 nCPM

Immune cell

basophil: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

cerebellum: 154 nTPM
white matter: 66 nTPM
cerebral cortex: 61 nTPM
basal ganglia: 59 nTPM
thalamus: 53 nTPM
midbrain: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTCL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTCL2 as an antibody target. Whether an autoantibody or antibody against MTCL2 could matter depends on whether native MTCL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTCL2 is annotated as secreted, so native MTCL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MTCL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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