Seroatlas · Human Serome Atlas

QRSL1

Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

Also known as: DKFZP564C1278, FLJ10989, FLJ12189, FLJ13447, GatA, GATA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H0R6
Gene
QRSL1
Ensembl
ENSG00000130348
Chromosome
6
Canonical length
528 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Vesicles,Centrosome

OverviewNCBI Gene

Contributes to glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Implicated in combined oxidative phosphorylation deficiency 40. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

528 residues, UniProt reviewed canonical sequence.

>Q9H0R6|QRSL1
     1  MLGRSLREVS AALKQGQITP TELCQKCLSL IKKTKFLNAY ITVSEEVALK QAEESEKRYK
    61  NGQSLGDLDG IPIAVKDNFS TSGIETTCAS NMLKGYIPPY NATVVQKLLD QGALLMGKTN
   121  LDEFAMGSGS TDGVFGPVKN PWSYSKQYRE KRKQNPHSEN EDSDWLITGG SSGGSAAAVS
   181  AFTCYAALGS DTGGSTRNPA AHCGLVGFKP SYGLVSRHGL IPLVNSMDVP GILTRCVDDA
   241  AIVLGALAGP DPRDSTTVHE PINKPFMLPS LADVSKLCIG IPKEYLVPEL SSEVQSLWSK
   301  AADLFESEGA KVIEVSLPHT SYSIVCYHVL CTSEVASNMA RFDGLQYGHR CDIDVSTEAM
   361  YAATRREGFN DVVRGRILSG NFFLLKENYE NYFVKAQKVR RLIANDFVNA FNSGVDVLLT
   421  PTTLSEAVPY LEFIKEDNRT RSAQDDIFTQ AVNMAGLPAV SIPVALSNQG LPIGLQFIGR
   481  AFCDQQLLTV AKWFEKQVQF PVIQLQELMD DCSAVLENEK LASVSLKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QRSL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 20 nTPM
  • skeletal muscle: 18 nTPM
  • lymph node: 15 nTPM
  • tonsil: 15 nTPM
  • spleen: 9.9 nTPM
  • heart muscle: 9.5 nTPM

Single-cell type

  • b-cells: 95 nCPM
  • myonuclei: 85 nCPM
  • adrenal cortex cells: 60 nCPM
  • breast lactating cells: 54 nCPM
  • renal collecting duct intercalated cells: 48 nCPM
  • choroid plexus epithelial cells: 48 nCPM

Immune cell

  • memory B-cell: 87 nTPM
  • naive B-cell: 71 nTPM
  • non-classical monocyte: 13 nTPM
  • myeloid DC: 11 nTPM
  • intermediate monocyte: 9.6 nTPM
  • plasmacytoid DC: 8.5 nTPM

Brain region

  • white matter: 18 nTPM
  • choroid plexus: 15 nTPM
  • basal ganglia: 14 nTPM
  • medulla oblongata: 14 nTPM
  • pons: 13 nTPM
  • cerebellum: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about QRSL1.

Disease | AllUniProt

Conditions QRSL1 is implicated in, by any mechanism.

  • Combined oxidative phosphorylation deficiency 40 (COXPD40) MIM:618835

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 190 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
1.07
DepMap mean gene effect
-0.41
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of QRSL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QRSL1 as an antibody target. Whether an autoantibody or antibody against QRSL1 could matter depends on whether native QRSL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QRSL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label QRSL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/QRSL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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