Seroatlas · Human Serome Atlas

MAP7D1

MAP7 domain-containing protein 1

Also known as: FLJ10350, FLJ39022, MA7D1_HUMAN, PARCC1, RPRC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3KQU3
Gene: MAP7D1
Ensembl: ENSG00000116871
Chromosome: 1
Canonical length: 841 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in microtubule cytoskeleton organization. Located in spindle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

841 residues, UniProt reviewed canonical sequence.

>Q3KQU3|MAP7D1
     1  MESGPRAELG AGAPPAVVAR TPPEPRPSPE GDPSPPPPPM SALVPDTPPD TPPAMKNATS
    61  SKQLPLEPES PSGQVGPRPA PPQEESPSSE AKSRGPTPPA MGPRDARPPR RSSQPSPTAV
   121  PASDSPPTKQ EVKKAGERHK LAKERREERA KYLAAKKAVW LEKEEKAKAL REKQLQERRR
   181  RLEEQRLKAE QRRAALEERQ RQKLEKNKER YEAAIQRSVK KTWAEIRQQR WSWAGALHHS
   241  SPGHKTSGSR CSVSAVNLPK HVDSIINKRL SKSSATLWNS PSRNRSLQLS AWESSIVDRL
   301  MTPTLSFLAR SRSAVTLPRN GRDQGRGCDP GRGPTWGRAG ASLARGPQPD RTHPSAAVPV
   361  CPRSASASPL TPCSVTRSVH RCAPAGERGE RRKPNAGGSP APVRRRPEAS PVQKKEKKDK
   421  ERENEKEKSA LARERSLKKR QSLPASPRAR LSASTASELS PKSKARPSSP STSWHRPASP
   481  CPSPGPGHTL PPKPPSPRGT TASPKGRVRR KEEAKESPSA AGPEDKSQSK RRASNEKESA
   541  APASPAPSPA PSPTPAPPQK EQPPAETPTD AAVLTSPPAP APPVTPSKPM AGTTDREEAT
   601  RLLAEKRRQA REQREREEQE RRLQAERDKR MREEQLAREA EARAEREAEA RRREEQEARE
   661  KAQAEQEEQE RLQKQKEEAE ARSREEAERQ RLEREKHFQQ QEQERQERRK RLEEIMKRTR
   721  KSEVSETKQK QDSKEANANG SSPEPVKAVE ARSPGLQKEA VQKEEPIPQE PQWSLPSKEL
   781  PASLVNGLQP LPAHQENGFS TNGPSGDKSL SRTPETLLPF AEAEAFLKKA VVQSPQVTEV
   841  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP7D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 268 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 268 nTPM
tongue: 99 nTPM
heart muscle: 91 nTPM
spinal cord: 87 nTPM
cerebral cortex: 66 nTPM
adipose tissue: 64 nTPM

Single-cell type

esophageal suprabasal cells: 190 nCPM
esophageal apical cells: 186 nCPM
syncytiotrophoblasts: 175 nCPM
suprabasal keratinocytes: 173 nCPM
ocular epithelial cells: 172 nCPM
extravillous trophoblasts: 164 nCPM

Immune cell

neutrophil: 1.4 nTPM
naive CD4 T-cell: 0.5 nTPM
classical monocyte: 0.4 nTPM
eosinophil: 0.4 nTPM
MAIT T-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM

Brain region

white matter: 396 nTPM
medulla oblongata: 365 nTPM
pons: 363 nTPM
thalamus: 338 nTPM
midbrain: 324 nTPM
basal ganglia: 318 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.99
gnomAD missense Z: 1
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule cytoskeleton organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAP7D1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP7D1 as an antibody target. Whether an autoantibody or antibody against MAP7D1 could matter depends on whether native MAP7D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP7D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP7D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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