Seroatlas · Human Serome Atlas

INPP5K

Inositol polyphosphate 5-phosphatase K

Also known as: INP5K_HUMAN, SKIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BT40
Gene
INPP5K
Ensembl
ENSG00000132376
Chromosome
17
Canonical length
448 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

448 residues, UniProt reviewed canonical sequence.

>Q9BT40|INPP5K
     1  MSSRKLSGPK GRRLSIHVVT WNVASAAPPL DLSDLLQLNN RNLNLDIYVI GLQELNSGII
    61  SLLSDAAFND SWSSFLMDVL SPLSFIKVSH VRMQGILLLV FAKYQHLPYI QILSTKSTPT
   121  GLFGYWGNKG GVNICLKLYG YYVSIINCHL PPHISNNYQR LEHFDRILEM QNCEGRDIPN
   181  ILDHDLIIWF GDMNFRIEDF GLHFVRESIK NRCYGGLWEK DQLSIAKKHD PLLREFQEGR
   241  LLFPPTYKFD RNSNDYDTSE KKRKPAWTDR ILWRLKRQPC AGPDTPIPPA SHFSLSLRGY
   301  SSHMTYGISD HKPVSGTFDL ELKPLVSAPL IVLMPEDLWT VENDMMVSYS STSDFPSSPW
   361  DWIGLYKVGL RDVNDYVSYA WVGDSKVSCS DNLNQVYIDI SNIPTTEDEF LLCYYSNSLR
   421  SVVGISRPFQ IPPGSLREDP LGEAQPQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INPP5K can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
138 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 138 nTPM
  • skeletal muscle: 42 nTPM
  • adipose tissue: 38 nTPM
  • skin: 33 nTPM
  • bone marrow: 33 nTPM
  • thyroid gland: 33 nTPM

Single-cell type

  • retinal pigment epithelial cells: 929 nCPM
  • late spermatids: 612 nCPM
  • early spermatids: 125 nCPM
  • neutrophils: 86 nCPM
  • esophageal apical cells: 71 nCPM
  • enterocytes: 59 nCPM

Immune cell

  • basophil: 105 nTPM
  • T-reg: 75 nTPM
  • neutrophil: 75 nTPM
  • eosinophil: 75 nTPM
  • non-classical monocyte: 67 nTPM
  • total PBMC: 63 nTPM

Brain region

  • choroid plexus: 101 nTPM
  • hippocampal formation: 34 nTPM
  • midbrain: 28 nTPM
  • thalamus: 28 nTPM
  • medulla oblongata: 28 nTPM
  • pons: 28 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about INPP5K.

Disease | AllUniProt

Conditions INPP5K is implicated in, by any mechanism.

  • Muscular dystrophy, congenital, with cataracts and impaired intellectual development (MDCCAID) MIM:617404

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 174 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0
gnomAD missense Z
0.6
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INPP5K in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INPP5K as an antibody target. Whether an autoantibody or antibody against INPP5K could matter depends on whether native INPP5K is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INPP5K is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INPP5K as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INPP5K. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...