Seroatlas · Human Serome Atlas

FNDC8

Fibronectin type III domain-containing protein 8

Also known as: DKFZp434H2215, FNDC8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TC99
Gene: FNDC8
Ensembl: ENSG00000073598
Chromosome: 17
Canonical length: 324 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>Q8TC99|FNDC8
     1  MASEALHQVG DGEEAVLKKE NFNMMNALDQ LPKPFSNPKS MNRTVTTKGL PLASKGNLVN
    61  FLEDDTINLL KPLPVEDSDC SSDETSISAF SSTLLNPIKL AVTQPNSSFF AGMLEGELNK
   121  LSFSPMAKNA ENEDLALGPC PCPSKSQMAT RGLLDLDNPE LETETSSTHS ESSVVVDLPD
   181  TPFIFEHTVN NSTAVISWTY ALGKQPVSFY QLLLQEVAKT QENELPEAKN RPWIFNKILG
   241  TTVKLMELKP NTCYCLSVRA ANTAGVGKWC KPYKFATLAT DFSSFPENYP IQITVRRKEP
   301  RQKIVSIGPE EMRRLEDLEY LFPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FNDC8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

testis: 86 nTPM
esophagus: 0.1 nTPM
skin: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

late spermatids: 3,566 nCPM
early spermatids: 720 nCPM
late primary spermatocytes: 35 nCPM
epicardial cells: 9.1 nCPM
sertoli cells: 5.9 nCPM
leydig cells: 3.8 nCPM

Immune cell

naive B-cell: 0.4 nTPM
naive CD4 T-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 0.5 nTPM
cerebellum: 0.4 nTPM
basal ganglia: 0.3 nTPM
hippocampal formation: 0.3 nTPM
amygdala: 0.2 nTPM
hypothalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of FNDC8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MAD2L1BP

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FNDC8 as an antibody target. Whether an autoantibody or antibody against FNDC8 could matter depends on whether native FNDC8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FNDC8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FNDC8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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