Seroatlas · Human Serome Atlas

LYRM4

LYR motif-containing protein 4

Also known as: C6orf149, CGI-203, ISD11, LYRM4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HD34
Gene
LYRM4
Ensembl
ENSG00000214113
Chromosome
6
Canonical length
91 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nuclear bodies
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

91 residues, UniProt reviewed canonical sequence.

>Q9HD34|LYRM4
     1  MAASSRAQVL SLYRAMLRES KRFSAYNYRT YAVRRIRDAF RENKNVKDPV EIQTLVNKAK
    61  RDLGVIRRQV HIGQLYSTDK LIIENRDMPR T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LYRM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 29 nTPM
  • pituitary gland: 27 nTPM
  • choroid plexus: 26 nTPM
  • cerebral cortex: 26 nTPM
  • amygdala: 24 nTPM
  • adrenal gland: 24 nTPM

Single-cell type

  • choroid plexus epithelial cells: 183 nCPM
  • late spermatids: 164 nCPM
  • gastric progenitor cells: 137 nCPM
  • differentiating spermatogonia: 132 nCPM
  • lactotrophs: 130 nCPM
  • esophageal basal cells: 129 nCPM

Immune cell

  • myeloid DC: 35 nTPM
  • memory B-cell: 31 nTPM
  • naive CD4 T-cell: 27 nTPM
  • naive B-cell: 26 nTPM
  • naive CD8 T-cell: 25 nTPM
  • NK-cell: 24 nTPM

Brain region

  • cerebral cortex: 28 nTPM
  • choroid plexus: 25 nTPM
  • white matter: 24 nTPM
  • medulla oblongata: 24 nTPM
  • spinal cord: 24 nTPM
  • pons: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LYRM4.

Disease | AllUniProt

Conditions LYRM4 is implicated in, by any mechanism.

  • Combined oxidative phosphorylation deficiency 19 (COXPD19) MIM:615595

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 104 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Combined oxidative phosphorylation deficiency 19

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0.2
gnomAD missense Z
0.36
DepMap mean gene effect
-1.22
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LYRM4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LYRM4 as an antibody target. Whether an autoantibody or antibody against LYRM4 could matter depends on whether native LYRM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LYRM4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LYRM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LYRM4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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