Seroatlas · Human Serome Atlas

NDUFAB1

Acyl carrier protein, mitochondrial

Also known as: ACP, ACP1, ACPM_HUMAN, FASN2A, SDAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14561
Gene: NDUFAB1
Ensembl: ENSG00000004779
Chromosome: 16
Canonical length: 156 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables mitochondrial large ribosomal subunit binding activity. Involved in [2Fe-2S] cluster assembly and protein lipoylation. Located in mitochondrial inner membrane and nucleoplasm. Part of mitochondrial [2Fe-2S] assembly complex and respiratory chain complex I. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

156 residues, UniProt reviewed canonical sequence.

>O14561|NDUFAB1
     1  MASRVLSAYV SRLPAAFAPL PRVRMLAVAR PLSTALCSAG TQTRLGTLQP ALVLAQVPGR
    61  VTQLCRQYSD MPPLTLEGIQ DRVLYVLKLY DKIDPEKLSV NSHFMKDLGL DSLDQVEIIM
   121  AMEDEFGFEI PDIDAEKLMC PQEIVDYIAD KKDVYE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDUFAB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 613 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 613 nTPM
skeletal muscle: 412 nTPM
tongue: 403 nTPM
liver: 173 nTPM
kidney: 166 nTPM
cerebral cortex: 164 nTPM

Single-cell type

parietal cells: 667 nCPM
esophageal basal cells: 493 nCPM
esophageal suprabasal cells: 492 nCPM
enteric transient amplifying cells: 380 nCPM
migrating cytotrophoblasts: 371 nCPM
gastric progenitor cells: 363 nCPM

Immune cell

plasmacytoid DC: 269 nTPM
myeloid DC: 240 nTPM
intermediate monocyte: 223 nTPM
total PBMC: 205 nTPM
classical monocyte: 181 nTPM
T-reg: 178 nTPM

Brain region

choroid plexus: 91 nTPM
cerebellum: 85 nTPM
hypothalamus: 82 nTPM
cerebral cortex: 82 nTPM
pons: 79 nTPM
medulla oblongata: 76 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.53
gnomAD missense Z: 0.16
DepMap mean gene effect: -0.75
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

acyl binding
calcium ion binding
fatty acid binding
mitochondrial large ribosomal subunit binding
structural molecule activity
acyl carrier activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NDUFAB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDUFAB1 as an antibody target. Whether an autoantibody or antibody against NDUFAB1 could matter depends on whether native NDUFAB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDUFAB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDUFAB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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