CCDC112
Coiled-coil domain-containing protein 112
Also known as: CC112_HUMAN, MGC39633
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NEF3
- Gene
- CCDC112
- Ensembl
- ENSG00000164221
- Chromosome
- 5
- Canonical length
- 446 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Plasma membrane,Cytosol
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
446 residues, UniProt reviewed canonical sequence.
>Q8NEF3|CCDC112
1 MEKDKHSHFY NQKSDFRIEH SMLEELENKL IHSRKTERAK IQQQLAKIHN NVKKLQHQLK
61 DVKPTPDFVE KLREMMEEIE NAINTFKEEQ RLIYEELIKE EKTTNNELSA ISRKIDTWAL
121 GNSETEKAFR AISSKVPVDK VTPSTLPEEV LDFEKFLQQT GGRQGAWDDY DHQNFVKVRN
181 KHKGKPTFME EVLEHLPGKT QDEVQQHEKW YQKFLALEER KKESIQIWKT KKQQKREEIF
241 KLKEKADNTP VLFHNKQEDN QKQKEEQRKK QKLAVEAWKK QKSIEMSMKC ASQLKEEEEK
301 EKKHQKERQR QFKLKLLLES YTQQKKEQEE FLRLEKEIRE KAEKAEKRKN AADEISRFQE
361 RDLHKLELKI LDRQAKEDEK SQKQRRLAKL KEKVENNVSR DPSRLYKPTK GWEERTKKIG
421 PTGSGPLLHI PHRAIPTWRQ GIQRRVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CCDC112 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 38 nTPM
Expression across tissuesHPA
Tissue
- testis: 38 nTPM
- spinal cord: 11 nTPM
- pancreas: 9.9 nTPM
- rectum: 8.8 nTPM
- colon: 8.5 nTPM
- cerebellum: 7.8 nTPM
Single-cell type
- late primary spermatocytes: 324 nCPM
- early primary spermatocytes: 141 nCPM
- undifferentiated spermatogonia: 79 nCPM
- differentiating spermatogonia: 75 nCPM
- erythrocyte progenitors: 72 nCPM
- pancreatic acinar cells: 72 nCPM
Immune cell
- eosinophil: 11 nTPM
- plasmacytoid DC: 10 nTPM
- myeloid DC: 5.4 nTPM
- classical monocyte: 5 nTPM
- non-classical monocyte: 4.9 nTPM
- intermediate monocyte: 4 nTPM
Brain region
- white matter: 15 nTPM
- cerebellum: 14 nTPM
- hypothalamus: 12 nTPM
- medulla oblongata: 12 nTPM
- pons: 12 nTPM
- cerebral cortex: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.37
- gnomAD pLI
- 0.85
- gnomAD missense Z
- -0.11
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CCDC112 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CCDC112 as an antibody target. Whether an autoantibody or antibody against CCDC112 could matter depends on whether native CCDC112 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CCDC112 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CCDC112 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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