Lon protease, N-terminal domain

Definition

This entry represents the N-terminal substrate-binding domain of the Lon protease. This ATP-dependent enzyme, a serine peptidase belonging to the MEROPS peptidase family S16, is conserved in archaeal, bacterial and eukaryotic organisms and catalyses rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins. In eukaryotes, the majority of the proteins are located in the mitochondrial matrix [[cite:PMID:8248235], [cite:PMID:9620272]]. In yeast, Pim1, is located in the mitochondrial matrix and required for mitochondrial function. It is constitutively expressed but is increased after thermal stress, suggesting that Pim1 may play a role in the heat shock response PMID:8276800. The structure of this domain has been determined and it represents a general protein and polypeptide interaction domain [[cite:PMID:16199667], [cite:PMID:19191354], [cite:PMID:20834233], [cite:PMID:23999302]].

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• CRBN
• LONP1
• LONP2
• LONRF1
• LONRF2
• LONRF3