Seroatlas · Human Serome Atlas

KIAA0930

Uncharacterized protein KIAA0930

Also known as: bK268H5.C22.1, C22orf9, K0930_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ICG6
Gene
KIAA0930
Ensembl
ENSG00000100364
Chromosome
22
Canonical length
404 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Mitochondria

OverviewNCBI Gene

No narrative summary is available for KIAA0930 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

404 residues, UniProt reviewed canonical sequence.

>Q6ICG6|KIAA0930
     1  MLRAIAEERG RLSLRREVCG LGCFKDDRIV FWTWMFSTYF MEKWAPRQDD MLFYVRRKLA
    61  YSGSESGADG RKAAEPEVEV EVYRRDSKKL PGLGDPDIDW EESVCLNLIL QKLDYMVTCA
   121  VCTRADGGDI HIHKKKSQQV FASPSKHPMD SKGEESKISY PNIFFMIDSF EEVFSDMTVG
   181  EGEMVCVELV ASDKTNTFQG VIFQGSIRYE ALKKVYDNRV SVAARMAQKM SFGFYKYSNM
   241  EFVRMKGPQG KGHAEMAVSR VSTGDTSPCG TEEDSSPASP MHERVTSFST PPTPERNNRP
   301  AFFSPSLKRK VPRNRIAEMK KSHSANDSEE FFREDDGGAD LHNATNLRSR SLSGTGRSLV
   361  GSWLKLNRAD GNFLLYAHLT YVTLPLHRIL TDILEVRQKP ILMT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA0930 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
183 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 183 nTPM
  • amygdala: 183 nTPM
  • midbrain: 181 nTPM
  • basal ganglia: 180 nTPM
  • hypothalamus: 144 nTPM
  • cerebral cortex: 140 nTPM

Single-cell type

  • astrocytes: 261 nCPM
  • oligodendrocytes: 252 nCPM
  • monocyte progenitors: 152 nCPM
  • other brain neurons: 130 nCPM
  • brain excitatory neurons: 113 nCPM
  • erythrocyte progenitors: 111 nCPM

Immune cell

  • non-classical monocyte: 17 nTPM
  • intermediate monocyte: 14 nTPM
  • myeloid DC: 12 nTPM
  • classical monocyte: 11 nTPM
  • plasmacytoid DC: 10 nTPM
  • eosinophil: 8.6 nTPM

Brain region

  • white matter: 204 nTPM
  • basal ganglia: 204 nTPM
  • cerebral cortex: 199 nTPM
  • amygdala: 177 nTPM
  • thalamus: 173 nTPM
  • midbrain: 171 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIAA0930.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 75 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
gnomAD missense Z
1.72
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF2045
  • Uncharacterized conserved protein (DUF2045)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIAA0930 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA0930 as an antibody target. Whether an autoantibody or antibody against KIAA0930 could matter depends on whether native KIAA0930 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA0930 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA0930 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIAA0930. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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