COX17

Protein identityUniProt · HPA

UniProt accession

Q14061

Gene

COX17

Ensembl

ENSG00000138495

Chromosome

3

Canonical length

63 aa

Protein class

Cancer-related genes, Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

63 residues, UniProt reviewed canonical sequence.

>Q14061|COX17
     1  MPGLVDSNPA PPESQEKKPL KPCCACPETK KARDACIIEK GEEHCGHLIE AHKECMRALG
    61  FKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.5

Highest tissue expression

486 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.54

gnomAD pLI

0.2

gnomAD missense Z

0.23

DepMap mean gene effect

-0.75

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• heart development
• mitochondrial respiratory chain complex IV assembly

Molecular functions

• copper chaperone activity
• copper ion binding
• cuprous ion binding
• enzyme activator activity

Cellular components

• cytoplasm
• mitochondrial intermembrane space
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Cysteine alpha-hairpin motif superfamily
• Cytochrome c oxidase copper chaperone
• Cytochrome C oxidase copper chaperone (COX17)

KeywordsUniProt

• Acetylation
• Chaperone
• Copper
• Cytochrome c-type biogenesis
• Cytoplasm
• Disulfide bond
• Metal-binding
• Mitochondrion
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of COX17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• COA1
• KATNAL1