FRMD5

Protein identityUniProt · HPA

UniProt accession

Q7Z6J6

Gene

FRMD5

Ensembl

ENSG00000171877

Chromosome

15

Canonical length

570 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables integrin binding activity and protein kinase binding activity. Involved in negative regulation of cell motility; positive regulation of cell adhesion; and regulation of cell migration. Located in adherens junction. Implicated in neurodevelopmental disorder with eye movement abnormalities and ataxia. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>Q7Z6J6|FRMD5
     1  MLSRLMSGSS RSLEREYSCT VRLLDDSEYT CTIQRDAKGQ YLFDLLCHHL NLLEKDYFGI
    61  RFVDPDKQRH WLEFTKSVVK QLRSQPPFTM CFRVKFYPAD PAALKEEITR YLVFLQIKRD
   121  LYHGRLLCKT SDAALLAAYI LQAEIGDYDS GKHPEGYSSK FQFFPKHSEK LERKIAEIHK
   181  TELSGQTPAT SELNFLRKAQ TLETYGVDPH PCKDVSGNAA FLAFTPFGFV VLQGNKRVHF
   241  IKWNEVTKLK FEGKTFYLYV SQKEEKKIIL TYFAPTPEAC KHLWKCGIEN QAFYKLEKSS
   301  QVRTVSSSNL FFKGSRFRYS GRVAKEVMES SAKIKREPPE IHRAGMVPSR SCPSITHGPR
   361  LSSVPRTRRR AVHISIMEGL ESLRDSAHST PVRSTSHGDT FLPHVRSSRT DSNERVAVIA
   421  DEAYSPADSV LPTPVAEHSL ELMLLSRQIN GATCSIEEEK ESEASTPTAT EVEALGGELR
   481  ALCQGHSGPE EEQVNKFVLS VLRLLLVTMG LLFVLLLLLI ILTESDLDIA FFRDIRQTPE
   541  FEQFHYQYFC PLRRWFACKI RSVVSLLIDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRMD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

44 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FRMD5.

Disease | AllUniProt

Conditions FRMD5 is implicated in, by any mechanism.

• Neurodevelopmental disorder with eye movement abnormalities and ataxia (NEDEMA) MIM:620094

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 119 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Neurodevelopmental disorder with eye movement abnormalities and ataxia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.25

gnomAD pLI

1

gnomAD missense Z

1.98

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actomyosin structure organization
• negative regulation of cell motility
• positive regulation of cell adhesion
• regulation of cell migration

Molecular functions

• cytoskeletal protein binding
• integrin binding
• protein kinase binding

Cellular components

• adherens junction
• cytoskeleton
• membrane

Protein domainsUniProt · Pfam · InterPro

• FERM domain
• Ezrin/radixin/moesin-like
• PH-like domain superfamily
• FERM/acyl-CoA-binding protein superfamily
• FERM adjacent
• FERM, N-terminal
• FERM, C-terminal PH-like domain
• FERM conserved site
• FERM central domain
• Band 4.1 domain
• Ubiquitin-like domain superfamily
• FERM superfamily, second domain
• FERM central domain
• FERM adjacent (FA)
• FERM N-terminal domain
• FERM C-terminal PH-like domain

KeywordsUniProt

• Cell junction
• Intellectual disability
• Membrane
• Phosphoprotein
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of FRMD5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CTNND1
• ITGB5