Seroatlas · Human Serome Atlas

TTC23L

Tetratricopeptide repeat protein 23-like

Also known as: FLJ25439, TT23L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PF05
Gene: TTC23L
Ensembl: ENSG00000205838
Chromosome: 5
Canonical length: 361 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in response to endoplasmic reticulum stress. Predicted to be located in cytoplasm; microtubule cytoskeleton; and midbody. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q6PF05|TTC23L
     1  MQASPIRIPT VSNDIDWDFC FHMSQQTEIP AHQQTDELYP TGGCGESEEE TKAKEKEKAI
    61  DCMSHPKEKL AQSQKKVAQL IKEKMNTQAN KELIRCVILS RIIFGDHHWK CARALANLAY
   121  GYLTLRGLPV QAKKHATSAK NTLLTWKANT TSNKEKEEIL EALVKLYYTL GVAWLLQNRG
   181  REAYFNLQKA ERNMKELKEL YKGGVCELQV SENDLTLALG RASLAIHRLN LALAYFEKAI
   241  GDVIAAKGDR TSDLISLYEE AAQIEQLRRN HNQAIQYLQQ AHSVCVSLFT EVSPKTAEMS
   301  ALLAKAYAMS GEAQHRDAVE IYFIRSINAY RATLGSEDFE TLSTTEEFCK WLVQNGEKQD
   361  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC23L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

testis: 25 nTPM
fallopian tube: 3.2 nTPM
retina: 1.4 nTPM
choroid plexus: 1.3 nTPM
pituitary gland: 0.9 nTPM
skin: 0.9 nTPM

Single-cell type

early spermatids: 518 nCPM
ependymal cells: 308 nCPM
late spermatids: 294 nCPM
breast lactating cells: 240 nCPM
late primary spermatocytes: 234 nCPM
respiratory ciliated cells: 202 nCPM

Immune cell

neutrophil: 0.7 nTPM
basophil: 0.6 nTPM
naive B-cell: 0.3 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

choroid plexus: 13 nTPM
medulla oblongata: 10 nTPM
white matter: 10 nTPM
spinal cord: 9.7 nTPM
midbrain: 9.4 nTPM
hypothalamus: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

response to endoplasmic reticulum stress

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TTC23L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

IQCE

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC23L as an antibody target. Whether an autoantibody or antibody against TTC23L could matter depends on whether native TTC23L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC23L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC23L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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