Seroatlas · Human Serome Atlas

ZNF609

Zinc finger protein 609

Also known as: KIAA0295, ZN609_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15014
Gene: ZNF609
Ensembl: ENSG00000180357
Chromosome: 15
Canonical length: 1411 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable promoter-specific chromatin binding activity. Involved in regulation of myoblast proliferation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1411 residues, UniProt reviewed canonical sequence.

>O15014|ZNF609
     1  MSLSSGASGG KGVDANPVET YDSGDEWDIG VGNLIIDLDA DLEKDQQKLE MSGSKEVGIP
    61  APNAVATLPD NIKFVTPVPG PQGKEGKSKS KRSKSGKDTS KPTPGTSLFT PSEGAASKKE
   121  VQGRSGDGAN AGGLVAAIAP KGSEKAAKAS RSVAGSKKEK ENSSSKSKKE RSEGVGTCSE
   181  KDPGVLQPVP LGGRGGQYDG SAGVDTGAVE PLGSIAIEPG AALNPLGTKP EPEEGENECR
   241  LLKKVKSEKM ESPVSTPAVL PIHLLVPVVN NDISSPCEQI MVRTRSVGVN TCDVALATEP
   301  ECLGPCEPGT SVNLEGIVWQ ETEDGMLVVN VTWRNKTYVG TLLDCTRHDW APPRFCDSPT
   361  SDLEMRNGRG RGKRMRPNSN TPVNETATAS DSKGTSNSSK TRAGANSKGR RGSQNSSEHR
   421  PPASSTSEDV KASPSSANKR KNKPLSDMEL NSSSEDSKGS KRVRTNSMGS ATGPLPGTKV
   481  EPTVLDRNCP SPVLIDCPHP NCNKKYKHIN GLKYHQAHAH TDDDSKPEAD GDSEYGEEPI
   541  LHADLGSCNG ASVSQKGSLS PARSATPKVR LVEPHSPSPS SKFSTKGLCK KKLSGEGDTD
   601  LGALSNDGSD DGPSVMDETS NDAFDSLERK CMEKEKCKKP SSLKPEKIPS KSLKSARPIA
   661  PAIPPQQIYT FQTATFTAAS PGSSSGLTAT VAQAMPNSPQ LKPIQPKPTV MGEPFTVNPA
   721  LTPAKDKKKK DKKKKESSKE LESPLTPGKV CRAEEGKSPF RESSGDGMKM EGLLNGSSDP
   781  HQSRLASIKA EADKIYSFTD NAPSPSIGGS SRLENTTPTQ PLTPLHVVTQ NGAEASSVKT
   841  NSPAYSDISD AGEDGEGKVD SVKSKDAEQL VKEGAKKTLF PPQPQSKDSP YYQGFESYYS
   901  PSYAQSSPGA LNPSSQAGVE SQALKTKRDE EPESIEGKVK NDICEEKKPE LSSSSQQPSV
   961  IQQRPNMYMQ SLYYNQYAYV PPYGYSDQSY HTHLLSTNTA YRQQYEEQQK RQSLEQQQRG
  1021  VDKKAEMGLK EREAALKEEW KQKPSIPPTL TKAPSLTDLV KSGPGKAKEP GADPAKSVII
  1081  PKLDDSSKLP GQAPEGLKVK LSDASHLSKE ASEAKTGAEC GRQAEMDPIL WYRQEAEPRM
  1141  WTYVYPAKYS DIKSEDERWK EERDRKLKEE RSRSKDSVPK EDGKESTSSD CKLPTSEESR
  1201  LGSKEPRPSV HVPVSSPLTQ HQSYIPYMHG YSYSQSYDPN HPSYRSMPAV MMQNYPGSYL
  1261  PSSYSFSPYG SKVSGGEDAD KARASPSVTC KSSSESKALD ILQQHASHYK SKSPTISDKT
  1321  SQERDRGGCG VVGGGGSCSS VGGASGGERS VDRPRTSPSQ RLMSTHHHHH HLGYSLLPAQ
  1381  YNLPYAAGLS STAIVASQQG STPSLYPPPR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF609 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
retina: 18 nTPM
ovary: 17 nTPM
thymus: 16 nTPM
parathyroid gland: 13 nTPM
fallopian tube: 12 nTPM

Single-cell type

choroid plexus epithelial cells: 703 nCPM
hematopoietic stem cells: 609 nCPM
cone photoreceptor cells: 596 nCPM
kupffer cells: 529 nCPM
podocytes: 527 nCPM
thymocytes: 527 nCPM

Immune cell

basophil: 1.3 nTPM
NK-cell: 1.1 nTPM
naive CD4 T-cell: 0.8 nTPM
naive CD8 T-cell: 0.8 nTPM
eosinophil: 0.5 nTPM
gdT-cell: 0.5 nTPM

Brain region

cerebellum: 46 nTPM
hypothalamus: 46 nTPM
cerebral cortex: 45 nTPM
white matter: 45 nTPM
hippocampal formation: 43 nTPM
amygdala: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
gnomAD missense Z: 1.83
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF609 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF609 as an antibody target. Whether an autoantibody or antibody against ZNF609 could matter depends on whether native ZNF609 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF609 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF609 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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